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Table 1 Inclusion and exclusion criteria for study

From: The Canadian childhood nephrotic syndrome (CHILDNEPH) study: report on mid-study feasibility, recruitment and main measures

  First Presentation First Relapse Second Relapse
Inclusion Criteria Age 1 to ≤17.5 years 1 to ≤17.5 years 1 to ≤17.5 years
Proteinuria >  3+ on dipstick; >  3 g/L on urinalysis; urine protein to creatinine ratio > 200 mg/mmol, for 3 consecutive days >  3+ on dipstick; >  3 g/L on urinalysis; urine protein to creatinine ratio > 200 mg/mmol, for 3 consecutive days >  3+ on dipstick; >  3 g/L on urinalysis; urine protein to creatinine ratio > 200 mg/mmol, for 3 consecutive days
Serum Albumin <  25 g/L <  25 g/L <  25 g/L
Exposure to Glucocorticoids No prior exposure to glucocorticoids Could have prior exposure to glucocorticoids (at First Presentation) Could have prior exposure to glucocorticoids (at First and Second Presentation)
Glucocorticoid sparing agents used None None None
Exclusion Criteria A primary disease associated with nephrotic syndrome (e.g. lupus, malignancy)
Serum C3 concentration low; suggesting alternative cause of nephrotic syndrome
Patients ultimately shown to be glucocorticoid resistant will be excluded from the final analysis (but will continue to be followed)