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Table 1 Baseline characteristics of participants according to the pregnancy outcome

From: Effect of deflazacort on pregnancy outcome in kidney transplant patients: should we change the immunosuppressant before conception?

  Never-pregnant (n = 10) Miscarriage (n = 9) Clinical pregnancy(n = 21) P value
Age (years) 34.5 (29–42) 36 (30–39) 33 (27–41) 0.44
Duration tried to concieve (months) 44 (16–108) 48 (6–96) 22 (6–96) 0.1
Years since transplantation (years) 4 (2–8)a 7 (2–18)a 5.5 (1–14) 0.08
SBP (mmHg) 123 (113–144) 135 (100–162) 120 (100–145) 0.44
DBP (mmHg) 80 (70–92) 76 (60–96) 72 (58–96) 0.2
Serum BUN (mg/dL) 18.85 (8.4–34.4) 25.4 (18.7–37.2)b 17.2 (10.2–35.3)b 0.04
eGFR 55.08 (22–96.6) 39 (9.0–76)b 60.72 (37–89.7)b 0.02
Hypertension     0.59
 No 4 (40%) 2 (22.2%) 5 (23.8%)  
 Yes 6 (60%) 7 (77.8%) 16 (76.2%)  
Diabetes melitus     0.04
 No 8 (80%) 9 (100%) 21 (100%)  
 Yes 2 (20%) 0 0  
Graft rejection     0.01
 No 7 (70%) 3 (33.32%) 19 (90.5%)  
 Yes 3 (30%) 6 (66.7%)b 2 (9.5%)b  
Cause of ESRD     0.13
 Unknown 1 (10%) 2 (22.2%) 5 (25%)  
 SLE 1 (10%) 3 (33.3%) 0  
 Glomerulonephritis 4 (40%) 2 (22.2%) 9 (42.9%)  
 Ig A nephropathy 2 (20%) 1 (11.1%) 7 (33.3%)  
 Congenital anomaly 1 (10%) 1 (11.1%) 0  
 Diabetes melitus 1 (10%) 0 0  
Immunosuppressant regimen     0.3
 CI 1 (10%) 2 (22.2%) 6 (28.6%)  
 CI + ST + AP 6 (60%) 1 (11.1%) 5 (23.8%)  
 CI + ST 3 (30%) 5 (55.6%) 9 (42.9%)  
 CI + AP 0 1 (11.1%) 1 (4.8%)  
Immunosuppressant use
 CyA 3 (30%) 2 (22.2%) 9 (45%) 0.52
 TAC 6 (60%) 7 (77.8%) 12 (57.1%) 0.55
 DFZ 9 (90%) 1 (11.1%) 2 (9.5%) < 0.0001
 Pred 2 (20%) 6 (66.7%) 13 (61.9%) 0.06
 Aza 5 (50%) 0 2 (9.5%) 0.01
 MMF 2 (20%) 2 (22.2%) 4 (19%) 0.98
  1. Data are presented as the median (minimum to maximum). The P-values were obtained using the analysis of variance and the Kruskal-Wallis test for continuous variables, and the chi-square test was used for analyzing categorical variables. Post hoc analysis using the Tukey method was performed, which showed a significant difference between the non-pregnant group and the miscarriage groupa, and the miscarriage group and clinical pregnancy groupb
  2. Note: Duration, period of attempted conception; SBP, systolic blood pressure; DBP, diastolic blood pressure; BUN, blood urea nitrogen; eGFR, estimated glomerular filtration rate; ESRD, end stage renal disease; SLE, systemic lupus erythematous; Ig, immunoglobulin; CI, calcineurin inhibitor; ST, steroid; AP; antiproliferative drug; CyA, cyclosporine; TAC, tacrolimus; DFZ, deflazacort; Pred, predinosolone; Aza, azathioprine; MMF, mycophenolate mofetil