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Table 2 Clinical characteristics of the study population stratified by tertiles of serum OPG levels

From: Serum osteoprotegerin is an independent marker of central arterial stiffness as assessed using carotid–femoral pulse wave velocity in hemodialysis patients: a cross sectional study

Characteristics Tertile 1
(72.97–237.13 pg/L)
(n = 40)
Tertile 2
(237.36–323.54 pg/L)
(n = 40)
Tertile 3
(329.61–835.78 pg/L)
(n = 40)
p for Trend
Demographics
 Age (years) 63.6 ± 12.9 63.3 ± 15.0 63.0 ± 15.6 0.834
 Female gender 25 (62.5) 22 (55.0) 13 (32.5) 0.008*
 HD duration (years) 4.5 (1.5–11.7) 5.1 (2.3–9.1) 4.7 (2.3–10.1) 1.000
Examination
 Height (cm) 157.8 ± 6.6 158.5 ± 9.4 162.6 ± 8.8 0.011*
 Body weight (kg) 63.9 ± 15.1 58.8 ± 13.2 70.1 ± 15.4 0.060
 BMI (kg/m2) 25.6 ± 5.7 23.3 ± 4.2 26.3 ± 4.6 0.521
 SBP (mmHg) 143.1 ± 27.2 145.0 ± 23.8 138.4 ± 24.7 0.414
 DBP (mmHg) 75.9 ± 15.4 78.6 ± 19.0 75.8 ± 15.4 0.989
 cfPWV (m/s) 8.45 (7.53–10.05) 10.20 (7.53–12.35) 10.45 (7.80–13.23) 0.020*
Laboratory data
 Total cholesterol (mg/dL) 150.1 ± 35.2 142.0 ± 32.4 140.6 ± 29.1 0.193
 Glucose (mg/dL) 130.5 (113.3–168.8) 127.0 (107.0–150.3) 136.5 (106.0–212.0) 0.290
 BUN (mg/dL) 61.6 ± 13.6 62.5 ± 14.8 61.5 ± 15.4 0.976
 Creatinine (mg/dL) 9.0 ± 1.7 9.2 ± 2.3 9.4 ± 1.9 0.378
 Corrected calcium (mg/dL) 8.9 ± 0.8 8.8 ± 0.8 8.8 ± 0.8 0.424
 Phosphorus (mg/dL) 5.0 ± 1.4 4.8 ± 1.1 4.7 ± 1.2 0.279
 C-reactive protein (mg/dL) 0.49 (0.10–1.32) 0.22 (0.08–0.46) 0.34 (0.08–1.12) 0.385
 Intact PTH (pg/mL) 250.9 (137.0–534.0) 146.5 (56.9–338.2) 160.4 (58.1–342.2) 0.049*
 Kt/V (Gotch) 1.35 ± 0.16 1.37 ± 0.15 1.31 ± 0.20 0.224
Comorbid conditions
 Diabetes mellitus, n (%) 20 (50.0) 19 (47.5) 17 (42.5) 0.503
 Hypertension, n (%) 19 (47.5) 20 (50.0) 21 (52.5) 0.656
 CAD, n (%) 30 (75.0) 22 (55.0) 26 (65.0) 0.169
Medications
 ACEIs or ARBs, n (%) 13 (32.5) 12 (30) 17 (42.5) 0.396
 β-Blockers, n (%) 13 (32.5) 12 (30) 8 (20) 0.212
 CCBs, n (%) 17 (42.5) 15 (37.5) 12 (30.0) 0.248
 Statins, n (%) 4 (10) 7 (17.5) 6 (15) 0.619
  1. Values for continuous variables are shown as mean ± standard deviation; variables not normally distributed are shown as median and interquartile range; values for categorical variables are presented as number (%). characteristics of the study population in different OPG groups were evaluated for linear trend using one-way analysis of variance (ANOVA) or the Cochran–Armitage test for trend
  2. OPG osteoprotegerin, HD hemodialysis, BMI body mass index, SBP systolic blood pressure, DBP diastolic blood pressure, cfPWV carotid–femoral pulse wave velocity, BUN blood urea nitrogen, PTH parathyroid hormone, Kt/V fractional clearance index for urea, CAD coronary artery disease, ACEIs angiotensin-converting enzyme inhibitors, ARBs angiotensin receptor blockers; CCBs, calcium channel blockers
  3. *p < 0.05 is considered as statistically significant