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Table 2 Clinical characteristics of the study population stratified by tertiles of serum OPG levels

From: Serum osteoprotegerin is an independent marker of central arterial stiffness as assessed using carotid–femoral pulse wave velocity in hemodialysis patients: a cross sectional study

Characteristics

Tertile 1

(72.97–237.13 pg/L)

(n = 40)

Tertile 2

(237.36–323.54 pg/L)

(n = 40)

Tertile 3

(329.61–835.78 pg/L)

(n = 40)

p for Trend

Demographics

 Age (years)

63.6 ± 12.9

63.3 ± 15.0

63.0 ± 15.6

0.834

 Female gender

25 (62.5)

22 (55.0)

13 (32.5)

0.008*

 HD duration (years)

4.5 (1.5–11.7)

5.1 (2.3–9.1)

4.7 (2.3–10.1)

1.000

Examination

 Height (cm)

157.8 ± 6.6

158.5 ± 9.4

162.6 ± 8.8

0.011*

 Body weight (kg)

63.9 ± 15.1

58.8 ± 13.2

70.1 ± 15.4

0.060

 BMI (kg/m2)

25.6 ± 5.7

23.3 ± 4.2

26.3 ± 4.6

0.521

 SBP (mmHg)

143.1 ± 27.2

145.0 ± 23.8

138.4 ± 24.7

0.414

 DBP (mmHg)

75.9 ± 15.4

78.6 ± 19.0

75.8 ± 15.4

0.989

 cfPWV (m/s)

8.45 (7.53–10.05)

10.20 (7.53–12.35)

10.45 (7.80–13.23)

0.020*

Laboratory data

 Total cholesterol (mg/dL)

150.1 ± 35.2

142.0 ± 32.4

140.6 ± 29.1

0.193

 Glucose (mg/dL)

130.5 (113.3–168.8)

127.0 (107.0–150.3)

136.5 (106.0–212.0)

0.290

 BUN (mg/dL)

61.6 ± 13.6

62.5 ± 14.8

61.5 ± 15.4

0.976

 Creatinine (mg/dL)

9.0 ± 1.7

9.2 ± 2.3

9.4 ± 1.9

0.378

 Corrected calcium (mg/dL)

8.9 ± 0.8

8.8 ± 0.8

8.8 ± 0.8

0.424

 Phosphorus (mg/dL)

5.0 ± 1.4

4.8 ± 1.1

4.7 ± 1.2

0.279

 C-reactive protein (mg/dL)

0.49 (0.10–1.32)

0.22 (0.08–0.46)

0.34 (0.08–1.12)

0.385

 Intact PTH (pg/mL)

250.9 (137.0–534.0)

146.5 (56.9–338.2)

160.4 (58.1–342.2)

0.049*

 Kt/V (Gotch)

1.35 ± 0.16

1.37 ± 0.15

1.31 ± 0.20

0.224

Comorbid conditions

 Diabetes mellitus, n (%)

20 (50.0)

19 (47.5)

17 (42.5)

0.503

 Hypertension, n (%)

19 (47.5)

20 (50.0)

21 (52.5)

0.656

 CAD, n (%)

30 (75.0)

22 (55.0)

26 (65.0)

0.169

Medications

 ACEIs or ARBs, n (%)

13 (32.5)

12 (30)

17 (42.5)

0.396

 β-Blockers, n (%)

13 (32.5)

12 (30)

8 (20)

0.212

 CCBs, n (%)

17 (42.5)

15 (37.5)

12 (30.0)

0.248

 Statins, n (%)

4 (10)

7 (17.5)

6 (15)

0.619

  1. Values for continuous variables are shown as mean ± standard deviation; variables not normally distributed are shown as median and interquartile range; values for categorical variables are presented as number (%). characteristics of the study population in different OPG groups were evaluated for linear trend using one-way analysis of variance (ANOVA) or the Cochran–Armitage test for trend
  2. OPG osteoprotegerin, HD hemodialysis, BMI body mass index, SBP systolic blood pressure, DBP diastolic blood pressure, cfPWV carotid–femoral pulse wave velocity, BUN blood urea nitrogen, PTH parathyroid hormone, Kt/V fractional clearance index for urea, CAD coronary artery disease, ACEIs angiotensin-converting enzyme inhibitors, ARBs angiotensin receptor blockers; CCBs, calcium channel blockers
  3. *p < 0.05 is considered as statistically significant
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BMC Nephrology

ISSN: 1471-2369

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