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Table 1 Significant differences in Ingenuity canonical signaling pathways between HPG and PYS

From: Transcriptome analysis of signaling pathways of human peritoneal mesothelial cells in response to different osmotic agents in a peritoneal dialysis solution

Signaling pathways HPG (d3) (total 78) PYS (d3) (total 424) PYS (d7) (total 161)
Diphthamide biosynthesis −2.09 Nil Nil
S-adenosyl-L-methionine biosynthesis −2.09 − 0.874 Nil
Unfolded protein response −2.01 − 0.321 − 1.53
Role of CHK proteins in cell cycle checkpoint −1.98 Nil Nil
Cell cycle: G1/S checkpoint regulation −1.86 0 Nil
Role of BRCA1 in DNA damage response −1.7 −2.4 Nil
Cyclins and cell cycle regulation −1.7 −0.497 Nil
Folate transformations I −1.62 −0.456 Nil
Neuroprotective role of THOP1 in Alzheimer’s disease −1.39 0 −0.354
Mismatched repair in eukaryotes −1.37 −0.272 Nil
GADD45 signaling −1.3 −0.654 Nil
Methylglyoxal degradation III −1.3 −0.224 −1.05
DNA damage-induced 14–3-3σ signaling −1.3 −0.224 Nil
Cell cycle: G2/M DNA damage checkpoint regulation −0.906 −2.13 Nil
Hereditary breast cancer signaling −1.24 −1.76 Nil
VDR/RXR activation Nil −1.54 Nil
Lipoate salvage and modification Nil −1.33 Nil
Inositol pyrophosphates biosynthesis Nil −1.3 Nil
CDK5 signaling Nil 0 −1.9
Antigen presentation pathway Nil −0.583 −1.83
Cardiac β-adrenergic signaling −0.325 0 −1.5
Induction of apoptosis by HIV1 Nil 0 −1.44
Mitotic roles of Polo-like kinases −0.787 −0.711 −1.38
Dopamine-DARPP32 feedback in cAMP signaling Nil 0 −1.33
Ephrin B signaling Nil −0.594 −1.3
CPCR-mediated integration of enteroendocrine signaling exemplified by an L cell Nil −0.351 −1.3
  1. The total number of affected pathways was presented in each group (n = 3, three separate RNA samples). The p value was calculated by t-test as compared with the baseline control at day 0, and it was presented in a log10 value (− 1.30 = 0.05). Nil: not in the list of affected pathways