Table 1 Significant differences in Ingenuity canonical signaling pathways between HPG and PYS
Signaling pathways | HPG (d3) (total 78) | PYS (d3) (total 424) | PYS (d7) (total 161) |
|---|---|---|---|
Diphthamide biosynthesis | −2.09 | Nil | Nil |
S-adenosyl-L-methionine biosynthesis | −2.09 | − 0.874 | Nil |
Unfolded protein response | −2.01 | − 0.321 | − 1.53 |
Role of CHK proteins in cell cycle checkpoint | −1.98 | Nil | Nil |
Cell cycle: G1/S checkpoint regulation | −1.86 | 0 | Nil |
Role of BRCA1 in DNA damage response | −1.7 | −2.4 | Nil |
Cyclins and cell cycle regulation | −1.7 | −0.497 | Nil |
Folate transformations I | −1.62 | −0.456 | Nil |
Neuroprotective role of THOP1 in Alzheimer’s disease | −1.39 | 0 | −0.354 |
Mismatched repair in eukaryotes | −1.37 | −0.272 | Nil |
GADD45 signaling | −1.3 | −0.654 | Nil |
Methylglyoxal degradation III | −1.3 | −0.224 | −1.05 |
DNA damage-induced 14–3-3σ signaling | −1.3 | −0.224 | Nil |
Cell cycle: G2/M DNA damage checkpoint regulation | −0.906 | −2.13 | Nil |
Hereditary breast cancer signaling | −1.24 | −1.76 | Nil |
VDR/RXR activation | Nil | −1.54 | Nil |
Lipoate salvage and modification | Nil | −1.33 | Nil |
Inositol pyrophosphates biosynthesis | Nil | −1.3 | Nil |
CDK5 signaling | Nil | 0 | −1.9 |
Antigen presentation pathway | Nil | −0.583 | −1.83 |
Cardiac β-adrenergic signaling | −0.325 | 0 | −1.5 |
Induction of apoptosis by HIV1 | Nil | 0 | −1.44 |
Mitotic roles of Polo-like kinases | −0.787 | −0.711 | −1.38 |
Dopamine-DARPP32 feedback in cAMP signaling | Nil | 0 | −1.33 |
Ephrin B signaling | Nil | −0.594 | −1.3 |
CPCR-mediated integration of enteroendocrine signaling exemplified by an L cell | Nil | −0.351 | −1.3 |