Table 3 Pathways for the “cellular stress and death”
Signaling pathways | HPG (d3) | PYS (d3) | PYS (d7) |
|---|---|---|---|
Unfolded protein response | HSPA8, EIF2AK3 | PPP1R15A, DNAJB9, AMFR | HSPA8, SREBF1 |
Apoptosis signaling | BCL2L11 | NAIP, BIRC6, DFFB, BCL2L11, PRKCA, CASP10 | MAP3K14, API5 |
NRF2-mediated oxidative stress response | DNAJC17, EIF2AK3 | FGFR1, ABCC2, MAF, JUNB, MAFK, DNAJB9, MAFF, FOS, DNAJC14, GSTO2, FKBP5, MGST3, CBR1, PRKCA | MGST3 |
Autophagy | CTSK | WDFY3, ATG4D, MAP1LC3B, ATG16L1 | |
Production of nitric oxide and reactive oxygen species in macrophages | FOS, ALB, RND3, ORM1, PPP1R10, FGFR, ARG2, PRKCA | MAP3K14, PPP1R10, PPP1R3C | |
Oxidative phosphorylation | MT-ND1, COX11, COX8C, UQCRFS1, SDHC | ||
Superoxide radical degradation | CYGB | ||
Nitric oxide signaling in the cardiovascular system | FLT1, FGFR1, ARG2, PRKCA | ||
Myc mediated apoptosis signaling | YWHAE, FGFR1 | ||
Mitochrondrial dysfunction | MT-ND1, COX11, PSENEN, COX8C, UQCRFS1, SDHC |