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Table 3 Pathways for the “cellular stress and death”

From: Transcriptome analysis of signaling pathways of human peritoneal mesothelial cells in response to different osmotic agents in a peritoneal dialysis solution

Signaling pathways HPG (d3) PYS (d3) PYS (d7)
Unfolded protein response HSPA8, EIF2AK3 PPP1R15A, DNAJB9, AMFR HSPA8, SREBF1
Apoptosis signaling BCL2L11 NAIP, BIRC6, DFFB, BCL2L11, PRKCA, CASP10 MAP3K14, API5
NRF2-mediated oxidative stress response DNAJC17, EIF2AK3 FGFR1, ABCC2, MAF, JUNB, MAFK, DNAJB9, MAFF, FOS, DNAJC14, GSTO2, FKBP5, MGST3, CBR1, PRKCA MGST3
Autophagy CTSK WDFY3, ATG4D, MAP1LC3B, ATG16L1  
Production of nitric oxide and reactive oxygen species in macrophages   FOS, ALB, RND3, ORM1, PPP1R10, FGFR, ARG2, PRKCA MAP3K14, PPP1R10, PPP1R3C
Oxidative phosphorylation   MT-ND1, COX11, COX8C, UQCRFS1, SDHC  
Superoxide radical degradation   CYGB  
Nitric oxide signaling in the cardiovascular system   FLT1, FGFR1, ARG2, PRKCA  
Myc mediated apoptosis signaling   YWHAE, FGFR1  
Mitochrondrial dysfunction   MT-ND1, COX11, PSENEN, COX8C, UQCRFS1, SDHC  
  1. Three separate RNA samples were included in each group (n = 3). The upregulated transcripts were highlighted in bold. Others were downregulated
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BMC Nephrology

ISSN: 1471-2369

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