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Table 1 Overall description of data sources and study period

From: Lactic acidosis associated with metformin in patients with moderate to severe chronic kidney disease: study protocol for a multicenter population-based case-control study using health databases

Database/Hospital Catalonia Madrid
Bellvitge University Hospital Hospital Germans Trias i Pujol Hospital Clinic of Barcelona University Hospital Vall d’Hebron Hospital de la Santa Creu i Sant Pau SIDIAP Hospital Clínico San Carlos Ramón y Cajal University Hospital Fundación Jiménez Díaz University Hospital Gerencia de Atención Primaria
Population covered (inhabitants) 373.000 810.000 540.000 450.000 403.000 N/A 366.000 574.000 424.000 N/A
Database type (Electronic medical register) Hospital Data available + + + + + N/A + + + N/A
Clinical data DW Hospital DW Hospital DW Hospital DW Hospital DW N/A Hospital DW CMBD Hospital DW N/A
Laboratory data DW Hospital DW ServoLab Modulab, clinical records Openlab N/A Laboratory database Openlab Hospital DW N/A
Primary care Data available + N/A N/A N/A N/A + N/A N/A N/A +
Clinical data DW N/A N/A N/A N/A ECAP N/A N/A N/A Ap-Madrid
Laboratory data DW N/A N/A N/A N/A ECAP N/A N/A N/A Ap-Madrid
Starting year of electronic data collection 2010 2008 2003 2009 2011 2006 2009 2009 2009 2002
Study period April 2011–December 2016 January 2014–December 2016 January 2010–December 2016 January 2010–December 2016 January 2012–December 2016 January 2010–December 2016 January 2010–December 2015 January 2010–December 2015 January 2010–December 2016 January 2010–December 2016
Disease and procedure coding system ICD 9 ICD 9 ICD 9 ICD 9 ICD 9 ICD 10 ICD 9 ICD 9 ICD 9 ICPC-2
Hospital admission and discharge data available Yes Yes Yes Yes Yes No Yes Yes Yes No
Drug dictionary code WHO-ATC,
National Drug Codes
N/A N/A N/A N/A WHO-ATC,
National Drug Codes
N/A N/A N/A WHO-ATC,
National Drug Codes
Drug information Prescriptions, data on strength and length N/A N/A N/A N/A Prescriptions, data on strength and length N/A N/A N/A Prescriptions, data on strength and length
  1. DW Data warehouse, CMBD, Conjunto mínimo básico de datos (Basic minimum set of data), ECAP, Estació clínica d’atenció primària (electronic health records in primary healthcare), Ap-Madrid Electronic Medical Record of Primary Care of Madrid, ICD 9 International Classification Diseases, 9th revision, ICD 10 International Classification Diseases, 10th revision, ICPC-2 International Classification Diseases, 2th revision, N/A not applicable