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Fig. 1 | BMC Nephrology

Fig. 1

From: Cilastatin protects against tacrolimus-induced nephrotoxicity via anti-oxidative and anti-apoptotic properties

Fig. 1

Effect of CL on fibrosis during TAC-induced renal injury. a Histological analysis of renal cortex treated with TAC shows striped tubulointerstitial fibrosis, mononuclear cell infiltration, and tubular atrophy. CL treatment significantly reduced these damages as compared with TAC treatment. (b and c) Immunoblot analysis of e-cadherin and transforming growth factor β1 (TGFβ-1) in the renal cortex. Note that combined treatment with CL reversed changes of e-cadherin and TGFβ-1 in response to TAC treatment. Magnification, 200×. N = 9 per group. #P < 0.05 vs. VH; @P < 0.05 vs. TAC

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BMC Nephrology

ISSN: 1471-2369

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