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Fig. 3 | BMC Nephrology

Fig. 3

From: Cilastatin protects against tacrolimus-induced nephrotoxicity via anti-oxidative and anti-apoptotic properties

Fig. 3

Effect of CL on oxidative stress during TAC-induced renal injury. a and b Immunohistochemistry for 8-hydroxy-2′-deoxyguanosine (8-OHdG) and 4-hydroxy-2-hexenal (4-HHE) in tissue sections. Intense nuclear expression of 8-OHdG and 4-HHE is shown in the TAC group, and administration of CL reduced their expression levels. c Enzyme-linked immunosorbent assay of serum 8-OHdG levels. Serum 8-OHdG was decreased in the CL-cotreated groups as compared to those in the TAC group. d Immunoblot analysis of manganese superoxide dismutase (MnSOD) in the renal cortex. Note that combined treatment with CL restored their expression as compared with TAC treatment alone. Magnification, 200×. N = 9 per group. #P < 0.05 vs. VH; @P < 0.05 vs. TAC

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BMC Nephrology

ISSN: 1471-2369

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