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Fig. 4 | BMC Nephrology

Fig. 4

From: Cilastatin protects against tacrolimus-induced nephrotoxicity via anti-oxidative and anti-apoptotic properties

Fig. 4

Effect of CL on apoptosis during TAC-induced renal injury. a In situ TdT-mediated dUTP-biotin nick end labeling (TUNEL) assay and its analysis in the renal tissue sections. CL cotreatment significantly reduced TUNEL-positive cells as compared to TAC treatment. b Representative images of immunohistochemical staining for the active form of caspase-3 (caspase-3) in kidney tissues. Quantitative analysis of caspase-3 in kidney tissues showed that CL cotreatment significantly reduced active caspase-3 staining as compared to TAC treatment alone. The arrows indicate TUNEL-positive apoptotic bodies. Magnification, 200×. N = 9 per group. #P < 0.05 vs. VH; @P < 0.05 vs. TAC

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BMC Nephrology

ISSN: 1471-2369

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