Table 1 Effect of CL on basic parameters and TAC concentration
VH | VH + CL75 | VH + CL150 | TAC | TAC + CL75 | TAC + CL150 | |
|---|---|---|---|---|---|---|
△BW (g) | 79 ± 5 | 77 ± 9 | 83 ± 5 | 59 ± 6# | 48 ± 6# | 48 ± 4# |
UV (mL/day) | 9 ± 2 | 13 ± 1 | 25 ± 1# | 26 ± 3# | 31 ± 7# | 22 ± 3# |
WI (mL/day) | 15 ± 3 | 18 ± 3 | 30 ± 3# | 30 ± 3# | 34 ± 7# | 26 ± 3# |
Scr (mg/dL) | 0.35 ± 0.07 | 0.32 ± 0.02 | 0.32 ± 0.03 | 0.64 ± 0.05# | 0.49 ± 0.02@ | 0.38 ± 0.05@ |
BUN (mg/dL) | 14.1 ± 3.1 | 14 ± 1.4 | 14.2 ± 0.7 | 56.2 ± 6.9# | 45.5 ± 1.4@ | 42.9 ± 4.5@ |
UMA (μg/mg) | 1.6 ± 0.2 | 2.3 ± 0.2 | 2.4 ± 0.2 | 9.2 ± 1.2# | 7.7 ± 1.3 | 4.8 ± 1.0@ |
CrCl (mL/min/100 g) | 0.77 ± 0.13 | 0.76 ± 0.06 | 0.81 ± 0.11 | 0.35 ± 0.02# | 0.50 ± 0.03@ | 0.62 ± 0.08@ |
TAC con.in blood (ng/mL) | _ | _ | _ | 14.1 ± 2.4 | 13.5 ± 2.1 | 13.9 ± 1.9 |
TAC con.in kidney (pg/mg) | _ | _ | _ | 7.4 ± 1.3 | 6.3 ± 1.1 | 5.1 ± 1.6 |