Association between serum calcium levels and prognosis, hematoma volume, and onset of cerebral hemorrhage in patients undergoing hemodialysis

Table 4 Univariate and multivariate logistic regression analyses for the onset of cerebral hemorrhage

	Univariate			Model 1			Model 2
	OR	95% CI	P value	OR	95% CI	P value	OR	95% CI	P value
Age per year	0.98	0.97–1.00	0.08	0.99	0.97–1.02	0.5
Male vs. female	1.49	0.93–2.39	0.09	1.63	0.86–3.11	0.1
HD vintage per year	1.02	0.99–1.05	0.14	1.02	0.98–1.07	0.3
History of diabetes	1.22	0.77–1.95	0.4	1.01	0.51–2.01	0.9
Number of antihypertensive drugs	1.09	0.93–1.27	0.3
Warfarin use	1.98	0.97–4.05	0.07				1.45	0.48–4.41	0.5
Dialyzing time per hour	1.54	1.05–2.23	0.03				1.55	0.95–2.52	0.08
Online HDF	0.36	0.17–0.74	0.002				0.42	0.17–1.01	0.052
ESA per 100 U	1.00	1.00–1.01	0.07				1.00	1.00–1.01	0.5
Intravenous Fe	1.61	0.95–2.70	0.07				1.60	0.81–3.22	0.2
sBP pre-HD per 10 mmHg	1.33	1.21–1.47	< 0.001	1.41	1.23–1.61	< 0.001	1.40	1.23–1.59	< 0.001
Hb per g/dL	0.88	0.75–1.04	0.13	0.82	0.66–1.02	0.07
Ferritin per 10 ng/mL	1.01	1.00–1.02	0.2
BUN per 10 mg/dL	0.79	0.70–0.90	< 0.001				0.85	0.71–1.01	0.06
Corrected serum calcium per mg/dL	1.40	1.07–1.83	0.01	1.52	1.05–2.20	0.03	1.54	1.07–2.22	0.02
Phosphate per mg/dL	0.82	0.70–0.95	0.007	0.81	0.66–0.98	0.03	0.86	0.71–1.05	0.1
iPTH per 10 pg/mL	1.02	1.01–1.04	0.02	1.03	1.00–1.05	0.03	1.03	1.01–1.05	0.02
T-Chol per 10 mg/dL	0.95	0.89–1.01	0.12

BUN blood urea nitrogen, CI confidential interval, ESA erythropoiesis-stimulating agent, HD hemodialysis, HDF hemodiafiltration, iPTH intact parathyroid hormone, OR odds ratio, sBP pre-HD systolic blood pressure pre-hemodialysis
Model 1: Adjusted by age and sex
Model 2: Adjusted by corrected serum calcium, dialyzing time, online hemodiafiltration, sBP pre-HD, BUN, phosphate, iPTH (parameters were selected by the stepwise method (mixed method))

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