Fig. 1

Distributions of the 1-year estimated glomerular filtration rate slopes. The median value of the eGFRcr slope was − 1.83 mL/min/1.73 m²/year (interquartile range [IQR]: − 8.39 to 3.86 mL/min/1.73 m²/year) (a). Of the subjects enrolled in the study (n = 1323), 503 (38%) met the criteria for rapid progression based on the eGFRcr slope. The median value of the eGFRcys slope was − 1.73 mL/min/1.73 m²/year (IQR: − 7.98 to 6.07 mL/min/1.73 m²/year), and 463 (35%) subjects met the criteria for rapid progression based on the eGFRcys slope (b). eGFR, estimated glomerular filtration rate; eGFRcr, creatinine-based eGFR; eGFRcys, cystatin C-based eGFR