Fig. 4
Adjusted hazard ratios (HR) of end-stage renal disease (ESRD) for eGFRcr and eGFRcys slopes among the rapid progression group stratified by either marker. After adjustment for baseline eGFR, both eGFRcr slopes and creatinine-based rapid progression were associated with higher risk of ESRD (eGFRcr slope: HR = 0.91 [95% confidence interval [CI]: 0.85–0.97], p = 0.003); creatinine-based rapid progression: HR = 4.25 [95% CI: 2.10–8.59], p < 0.001) (a). When adjusting for the baseline eGFR, the association between the eGFRcys slope and the risk of ESRD did not reach statistical significance (HR = 0.96 [95% CI: 0.88–1.04], p = 0.31) (b). *HR and 95% CI for 10 increments of eGFR slope (mL/min per 1.73 m2/year). eGFR, estimated glomerular filtration rate; eGFRcr, creatinine-based eGFR; eGFRcys, cystatin C-based eGFR