Creatinine- and cystatin C-based estimated glomerular filtration rate slopes for the prediction of kidney outcome: a comparative retrospective study

Table 2 Effect of creatinine-based glomerular filtration rate slope on renal survival in comparison with that of cystatin C-based glomerular filtration rate slope: Adjusted for baseline estimated glomerular filtration rate

Variable	HR	95% CI	P value	c-index (95% CI)	P value
eGFRcr slope	0.986	0.982–0.991	< 0.0001	0.6425 (0.5912–0.6939)	0.239^b
eGFRcys slope	0.988	0.983–0.993	< 0.0001	0.6309 (0.5796–0.6821)
Creatinine-based rapid progression^a	2.22	1.57–3.13	< 0.0001	0.6324 (0.5796–0.6852)	0.659^c
Cystatin C-based rapid progression^a	2.03	1.44–2.86	< 0.0001	0.6428 (0.5916–0.6941)

eGFRcr-cys values were used for baseline eGFR values
eGFR Estimated glomerular filtration rate, eGFRcr Creatinine-based eGFR, eGFRcys Cystatin C-based eGFR, HR Hazard ratio, 95% CI Confidence interval
^aRapid progression was defined as a eGFR slope steeper than −5 mL/min/1.73 m²/year
^bp value was obtained by comparing the c-index of the eGFRcr slopes with that of the eGFRcys slopes
^cp value was obtained by comparing the c-index of the creatinine-based rapid progression with that of the cystatin C-based rapid progression

ISSN: 1471-2369