Table 2 Differences between primary MN and IgG4-MN
Item | Primary MN | IgG4-MN | |
|---|---|---|---|
Clinical manifestations | Often without damaging other systems | Other with multi-system injuries including lacrimal gland inflammation, salivary gland inflammation, and pancreatitis | |
Laboratory tests | Renal function | Often normal | Often abnormal |
Serum IgG4 | Often not elevated | (Absolute or relative values) often elevated | |
Serum IgE | Often not elevated | Often elevated | |
PLA2R | Often positive | Negative | |
Pathology | Pathological IgG subtypes | Various | Mainly IgG4 |
Interstitial damage | Without plasma cell infiltration and often without interstitial damage | With plasma cell infiltration and often with interstitial damage | |
Treatment protocol | Hormone dosage | Typically adequate (Prednisone dose that was 1–2 mg/kg/d) | Generally medium and small dose (Prednisone dose that induced was 30–40 mg/d) |
Withdrawal of hormone | Hormone are withdrawn regularly, and will be stopped when the condition is alleviated | Maintenance is required | |