Serum complement C4 is an important prognostic factor for IgA nephropathy: a retrospective study

BMC Nephrology

Table 1 Univariate and multivariable Cox proportional hazards regression analysis of the data from the development cohort (the composite endpoint)

Predictors	Univariable analysis			Multivariable analysis
Predictors	HR	95%CI	P value	HR	95%CI	P value
Sex			< 0.001			0.664
Male	1.000			1.000
female	0.514	0.365, 0.725	< 0.001	1.096	0.724, 1.658	0.664
Age at renal biopsy	1.018	1.006, 1.031	0.005	0.978	0.962, 0.994	0.007
Hypertension			< 0.001			0.572
No	1.000			1.000
Yes	4.009	2.804, 5.731	0.001	1.132	0.735, 1.743	0.572
UPE (g/d)	1.199	1.162, 1.237	< 0.001	1.061	1.005, 1.120	0.033
eGFR (ml/min/1.73m²)	0.947	0.940, 0.953	< 0.001	0.960	0.950, 0.970	< 0.001
Serum uric acid	1.006	1.005, 1.007	< 0.001	1.001	1.000, 1.003	0.126
Serum IgA	0.830	0.713, 0.966	0.016	0.895	0.760, 1.054	0.182
Serum C3	2.197	1.113, 4.338	0.023	2.393	0.942, 6.080	0.067
Serum C4	902.010	285.539, 2576.250	< 0.001	6.978	1.013, 48.070	0.048
RASI			< 0.001			0.341
Not received	1.000			1.000
Received	0.274	0.196, 0.383	< 0.001	1.231	0.802, 1.890	0.341
Immunosuppressants			0.258	–	–	–
Not received	1.000
Received	1.255	0.847, 1.859	0.258
Oxford classification
Mesangial hypercellularity			< 0.001			0.031
M0	1.000			1.000
M1	3.056	1.898, 4.918	< 0.001	1.847	1.057, 3.227	0.031
Endocapillary hypercellularity			0.451	–	–	–
E0	1.000
E1	0.865	0.593, 1.262	0.451
Segmental sclerosis			< 0.001			0.124
S0	1.000
S1	4.009	2.804, 5.731	< 0.001	0.723	0.479, 1.093	0.124
Tubular atrophy/interstitial fibrosis			< 0.001			0.048
T0	1.000			1.000
T1	6.578	3.551, 12.185	< 0.001	1.641	0.829, 3.250	0.155
T2	35.612	20.203, 62.772	< 0.001	2.480	1.175, 5.236	0.017
Crescents			< 0.001			0.031
C0				1.000
C1	1.430	0.996, 2.053	0.053	1.384	0.924, 2.073	0.114
C2	2.909	1.824, 4.641	< 0.001	2.133	1.206, 3.770	0.009
Glomerulosclerosis	87.864	49.586, 155.690	< 0.001	3.734	1.528, 9.127	0.004

UPE urinary protein excretion, eGFR estimated glomerular filtration rate, RASI renin-angiotensin system inhibitors

ISSN: 1471-2369