From: Serum complement C4 is an important prognostic factor for IgA nephropathy: a retrospective study
Predictors | Univariable analysis | Multivariable analysis | ||||
---|---|---|---|---|---|---|
HR | 95%CI | P value | HR | 95%CI | P value | |
Sex | < 0.001 | 0.664 | ||||
Male | 1.000 | 1.000 | ||||
female | 0.514 | 0.365, 0.725 | < 0.001 | 1.096 | 0.724, 1.658 | 0.664 |
Age at renal biopsy | 1.018 | 1.006, 1.031 | 0.005 | 0.978 | 0.962, 0.994 | 0.007 |
Hypertension | < 0.001 | 0.572 | ||||
No | 1.000 | 1.000 | ||||
Yes | 4.009 | 2.804, 5.731 | 0.001 | 1.132 | 0.735, 1.743 | 0.572 |
UPE (g/d) | 1.199 | 1.162, 1.237 | < 0.001 | 1.061 | 1.005, 1.120 | 0.033 |
eGFR (ml/min/1.73m2) | 0.947 | 0.940, 0.953 | < 0.001 | 0.960 | 0.950, 0.970 | < 0.001 |
Serum uric acid | 1.006 | 1.005, 1.007 | < 0.001 | 1.001 | 1.000, 1.003 | 0.126 |
Serum IgA | 0.830 | 0.713, 0.966 | 0.016 | 0.895 | 0.760, 1.054 | 0.182 |
Serum C3 | 2.197 | 1.113, 4.338 | 0.023 | 2.393 | 0.942, 6.080 | 0.067 |
Serum C4 | 902.010 | 285.539, 2576.250 | < 0.001 | 6.978 | 1.013, 48.070 | 0.048 |
RASI | < 0.001 | 0.341 | ||||
Not received | 1.000 | 1.000 | ||||
Received | 0.274 | 0.196, 0.383 | < 0.001 | 1.231 | 0.802, 1.890 | 0.341 |
Immunosuppressants | 0.258 | – | – | – | ||
Not received | 1.000 | |||||
Received | 1.255 | 0.847, 1.859 | 0.258 | |||
Oxford classification | ||||||
Mesangial hypercellularity | < 0.001 | 0.031 | ||||
M0 | 1.000 | 1.000 | ||||
M1 | 3.056 | 1.898, 4.918 | < 0.001 | 1.847 | 1.057, 3.227 | 0.031 |
Endocapillary hypercellularity | 0.451 | – | – | – | ||
E0 | 1.000 | |||||
E1 | 0.865 | 0.593, 1.262 | 0.451 | |||
Segmental sclerosis | < 0.001 | 0.124 | ||||
S0 | 1.000 | |||||
S1 | 4.009 | 2.804, 5.731 | < 0.001 | 0.723 | 0.479, 1.093 | 0.124 |
Tubular atrophy/interstitial fibrosis | < 0.001 | 0.048 | ||||
T0 | 1.000 | 1.000 | ||||
T1 | 6.578 | 3.551, 12.185 | < 0.001 | 1.641 | 0.829, 3.250 | 0.155 |
T2 | 35.612 | 20.203, 62.772 | < 0.001 | 2.480 | 1.175, 5.236 | 0.017 |
Crescents | < 0.001 | 0.031 | ||||
C0 | 1.000 | |||||
C1 | 1.430 | 0.996, 2.053 | 0.053 | 1.384 | 0.924, 2.073 | 0.114 |
C2 | 2.909 | 1.824, 4.641 | < 0.001 | 2.133 | 1.206, 3.770 | 0.009 |
Glomerulosclerosis | 87.864 | 49.586, 155.690 | < 0.001 | 3.734 | 1.528, 9.127 | 0.004 |