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Table 1 Univariate and multivariable Cox proportional hazards regression analysis of the data from the development cohort (the composite endpoint)

From: Serum complement C4 is an important prognostic factor for IgA nephropathy: a retrospective study

Predictors Univariable analysis Multivariable analysis
HR 95%CI P value HR 95%CI P value
Sex    < 0.001    0.664
 Male 1.000    1.000   
 female 0.514 0.365, 0.725 < 0.001 1.096 0.724, 1.658 0.664
Age at renal biopsy 1.018 1.006, 1.031 0.005 0.978 0.962, 0.994 0.007
Hypertension    < 0.001    0.572
 No 1.000    1.000   
 Yes 4.009 2.804, 5.731 0.001 1.132 0.735, 1.743 0.572
UPE (g/d) 1.199 1.162, 1.237 < 0.001 1.061 1.005, 1.120 0.033
eGFR (ml/min/1.73m2) 0.947 0.940, 0.953 < 0.001 0.960 0.950, 0.970 < 0.001
Serum uric acid 1.006 1.005, 1.007 < 0.001 1.001 1.000, 1.003 0.126
Serum IgA 0.830 0.713, 0.966 0.016 0.895 0.760, 1.054 0.182
Serum C3 2.197 1.113, 4.338 0.023 2.393 0.942, 6.080 0.067
Serum C4 902.010 285.539, 2576.250 < 0.001 6.978 1.013, 48.070 0.048
RASI    < 0.001    0.341
 Not received 1.000    1.000   
 Received 0.274 0.196, 0.383 < 0.001 1.231 0.802, 1.890 0.341
Immunosuppressants    0.258
 Not received 1.000      
 Received 1.255 0.847, 1.859 0.258    
Oxford classification
Mesangial hypercellularity    < 0.001    0.031
 M0 1.000    1.000   
 M1 3.056 1.898, 4.918 < 0.001 1.847 1.057, 3.227 0.031
Endocapillary hypercellularity    0.451
 E0 1.000      
 E1 0.865 0.593, 1.262 0.451    
Segmental sclerosis    < 0.001    0.124
 S0 1.000      
 S1 4.009 2.804, 5.731 < 0.001 0.723 0.479, 1.093 0.124
Tubular atrophy/interstitial fibrosis    < 0.001    0.048
 T0 1.000    1.000   
 T1 6.578 3.551, 12.185 < 0.001 1.641 0.829, 3.250 0.155
 T2 35.612 20.203, 62.772 < 0.001 2.480 1.175, 5.236 0.017
Crescents    < 0.001    0.031
 C0     1.000   
 C1 1.430 0.996, 2.053 0.053 1.384 0.924, 2.073 0.114
 C2 2.909 1.824, 4.641 < 0.001 2.133 1.206, 3.770 0.009
Glomerulosclerosis 87.864 49.586, 155.690 < 0.001 3.734 1.528, 9.127 0.004
  1. UPE urinary protein excretion, eGFR estimated glomerular filtration rate, RASI renin-angiotensin system inhibitors