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Table 2 Cox proportional regression models on the association of glomerular filtration rate (eGFR) and dementia. Hazard ratios are presented with 95% confidence intervals

From: Moderately increased albuminuria, chronic kidney disease and incident dementia: the HUNT study

 

Total Dementia

NCA

Combined AD, VaD, Mixed AD/VaD

NC

AD

NC

VaD

NC

Mixed AD/VaD

NC

Other Dementia

NC

 

eGFR

 

668

 

528

 

348

 

112

 

68

 

140

Model 1c

> 90

Ref

 

Ref

 

Ref

 

Ref

 

Ref

 

Ref

 
 

69.0–89.9

9.96 (6.04–16.42)

 

10.52 (5.76–18.26)

 

9.88 (4.87–20.03)

 

6.86 (2.50–18.81)

 

not sig

 

9.17 (3.37–24.96)

 
 

30.0–59.9

41.73 (25.17–69.19)

 

46.10 (25.75–82.51)

 

48.22 (23.65–98.31)

 

26.10 (9.31–73.17)

 

not sig

 

29.77 (10.69–82.88)

 
 

< 30

62.85 (21.00–188.06)

 

63.22 (17.83–224.14)

 

32.70 (4.09–261.59)

 

131.97 (24.14–721.62)

 

not sig

 

65.94 (7.36–590.56)

 

Model 2d

> 90

Ref

 

Ref

 

Ref

 

Ref

 

Ref

 

Ref

 
 

69.0–89.9

1.38 (.82–2.34)

 

1.24 (.68–2.26)

 

1.09 (.52–2.29)

 

1.08 (.37–3.16)

 

not sig

 

2.03 (.71–5.80)

 
 

30.0–59.9

1.24 (.71–2.16)

 

1.09 (.58–2.07)

 

.98 (.45–2.15)

 

.97 (.30–3.13)

 

not sig

 

1.87 (.60–5.82)

 
 

< 30

1.68 (.55–5.17)

 

1.37 (.38–5.02)

 

.62 (.08–5.10)

 

4.16 (.69–24.99)

 

not sig

 

3.50 (.37–33.22)

 

Model 3e

> 90

Ref

 

Ref

 

Ref

 

Ref

 

Ref

 

Ref

 
 

69.0–89.9

1.35 (.80–2.28)

 

1.20 (.65–2.20)

 

1.08 (.51–2.28)

 

.97 (.33–2.83)

 

not sig

 

2.00 (.70–5.74)

 
 

30.0–59.9

1.20 (.68–2.10)

 

1.05 (.55–2.00)

 

.98 (.44–2.16)

 

.81 (.25–2.63)

 

not sig

 

1.82 (.58–5.71)

 
 

< 30

1.64 (.53–5.05)

 

1.34 (.37–4.92)

 

.64 (.08–5.33)

 

3.10 (.51–18.79)

 

not sig

 

3.43 (.36–32.72)

 

Model 4f

> 90

Ref

 

Ref

 

Ref

 

Ref

 

Ref

 

Ref

 
 

69.0–89.9

1.34 (.79–2.26)

 

1.18 (.64–2.16)

 

1.06 (.50–2.22)

 

.97 (.33–2.83)

 

not sig

 

2.04 (.71–5.82)

 
 

30.0–59.9

1.17 (.67–2.06)

 

1.02 (.54–1.94)

 

.96 (.43–2.12)

 

.75 (.23–2.44)

 

not sig

 

1.84 (.59–5.81)

 
 

< 30

1.57 (.51–4.85)

 

1.24 (.34–4.58)

 

.65 (.08–5.35)

 

2.29 (.37–14.08)

 

not sig

 

3.69 (.38–35.55)

 

eGFR*Age

 

> 90

Ref

 

Ref

 

Ref

 

Ref

 

Ref

 

Ref

 
 

69.0–89.9

.95 (.91–.99)

 

.97 (.92–1.02)

 

.96 (.90–1.02)

 

.99 (.90–1.10)

 

not sig

 

.90 (.82–.99)

 
 

30.0–59.9

.90 (.86–.94)

 

.91 (.86–.96)

 

.90 (.84–.96)

 

.96 (.6–1.06)

 

not sig

 

.85 (.77–.94)

 
 

< 30

.88 (.79–.98)

 

.88 (.78–.98)

 

.88 (.72–1.07)

 

.91 (.77–1.06)

 

not sig

 

.92 (.69–1.22)

 

eGFR*Sex

 

> 90

Ref

 

Ref

 

Ref

 

Ref

 

Ref

 

Ref

 
 

69.0–89.9

1.98 (.72–5.44)

 

3.25 (1.01–10.49)

 

2.15 (.52–8.85)

 

9.98 (.98–101.33)

 

not sig

 

not sig

 
 

30.0–59.9

1.67 (.59–4.69)

 

2.80 (.85–9.30)

 

1.34 (.31–5.80)

 

17.33 (1.63–183.87)

 

not sig

 

not sig

 
 

< 30

2.58 (.29–23.32)

 

9.41 (.65–135.41)

 

.00 (.00–.00)

 

.00 (.00–.00)

 

not sig

 

not sig

 
  1. A Number of dementia cases
  2. B Age when examined in HUNT 2
  3. C Model 1: Categorized estimated Glomerular filtration rate (eGFR)
  4. D Model 2: eGFR, age, sex, education
  5. E Model 3: eGFR, age, sex, education, glomerular filtration rate, cholesterol, non-fasting blood glucose, serum iron, body mass index, pulse
  6. F Model 4: eGFR, age, sex, education, glomerular filtration rate, cholesterol, non-fasting blood glucose, serum iron, body mass index, pulse, history of myocardial infarction, diabetes mellitus, angina, stroke, smoking, subjective health status
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