Table 4 Adjusted model of change in phosphate (mmol/L), calcium (mmol/L) and PTH (log10, pmol/L)
Phosphate | Calcium | PTH (log10) | ||||
|---|---|---|---|---|---|---|
Variable | Beta (95% CI) | P-value | Beta (95% CI) | P-value | Beta (95% CI) | P-value |
Extended hours dialysis (ref = Standard) | −0.219 (−0.314, − 0.124) | < 0.001 | 0.046 (0.007, 0.086) | 0.021 | 0.025 (− 0.107, 0.157) | 0.713 |
Baseline parameter (phosphate/calcium/PTH) | 0.267 (0.164, 0.369) | < 0.001 | 0.576 (0.428, 0.724) | < 0.001 | 0.523 (0.382, 0.663) | < 0.001 |
Use of active vitamin D (ref = No use) | 0.067 (−0.017, 0.152) | 0.119 | 0.048 (0.002, 0.094) | 0.041 | −0.03 (− 0.165, 0.104) | 0.661 |
Baseline use of active vitamin D | −0.046 (− 0.155, 0.064) | 0.415 | − 0.044 (− 0.096, 0.008) | 0.098 | 0.049 (− 0.105, 0.202) | 0.533 |
Dose of cinacalcet | 0.002 (− 0.001, 0.006) | 0.23 | < 0.001 (− 0.002, 0.001) | 0.806 | 0.002 (− 0.004, 0.007) | 0.54 |
Baseline dose of cinacalcet | −0.001 (− 0.003, 0.002) | 0.593 | 0.001 (− 0.001, 0.003) | 0.2 | < 0.001 (− 0.005, 0.005) | 0.876 |
Dialysate calcium | − 0.338 (− 0.748, 0.072) | 0.107 | − 0.1 (− 0.271, 0.071) | 0.253 | 0.043 (− 0.517, 0.603) | 0.88 |
Baseline dialysate calcium | 0.32 (− 0.067, 0.708) | 0.105 | 0.116 (− 0.094, 0.326) | 0.277 | −0.734 (−1.445, − 0.023) | 0.043 |
Number of phosphate binders | < 0.001 (− 0.011, 0.01) | 0.965 | 0.002 (− 0.003, 0.006) | 0.503 | − 0.008 (− 0.017, 0.001) | 0.072 |
Baseline number of phosphate binders | 0.007 (− 0.009, 0.023) | 0.393 | − 0.001 (− 0.01, 0.007) | 0.759 | −0.004 (− 0.032, 0.024) | 0.797 |
Age | −0.002 (− 0.006, 0.002) | 0.278 | < 0.001 (− 0.002, 0.001) | 0.605 | −0.007 (− 0.013, − 0.002) | 0.01 |
Female (ref = Male) | −0.018 (− 0.125, 0.09) | 0.749 | −0.023 (− 0.064, 0.019) | 0.284 | 0.02 (− 0.11, 0.15) | 0.76 |
More than 3x weekly dialysis (ref = 3x or fewer) | −0.113 (− 0.196, − 0.03) | 0.008 | 0.029 (− 0.008, 0.067) | 0.128 | −0.024 (− 0.137, 0.09) | 0.68 |
Non-China (ref = China) | −0.18 (− 0.328, − 0.032) | 0.017 | 0.004 (− 0.056, 0.064) | 0.89 | −0.267 (− 0.445, − 0.089) | 0.003 |
Home dialysis (ref = Institution) | 0.183 (0.011, 0.356) | 0.037 | −0.019 (− 0.079, 0.04) | 0.527 | 0.08 (− 0.157, 0.318) | 0.509 |
< 6 months on dialysis (ref= > 6 months) | −0.062 (− 0.201, 0.077) | 0.381 | 0.012 (− 0.031, 0.055) | 0.592 | −0.166 (− 0.342, 0.011) | 0.066 |