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Table 1 Baseline characteristics of all 244 patients by renal recovery

From: Clinical predictors of renal non-recovery in acute respiratory distress syndrome

Characteristic Recovery (96) Non-recovery (148) p value
Age, median (IQR), years 56 (44–66) 56 (43.8–64) 0.57
Male sex, n (%) 55 (57.3) 82 (55.4) 0.77
Body mass index, median (IQR), kg/m2 30.6 (24.5–37.2) 30.2 (25.2–39.4) 0.54
Race, n (%)
 White 70 (72.9) 100 (67.6) 0.37
 Black or African American 25 (26) 33 (22.3) 0.50
SOFA, mean (SD), points 10.6 (3) 12.7 (3.6) < 0.001*
Non-renal SOFA, mean (SD), points 9.8 (2.7) 11.3 (3) < 0.001*
APACHE III, mean (SD), points 105 (29) 121 (31) < 0.001*
Charlson comorbidities index, median (IQR), points 3 (1–5) 3 (1–5) 0.61
Severity of ARDS on day 1
 Mild 13 (15.3) 20 (15.2) 0.22
 Moderate 41 (48.2) 49 (37.1)
 Severe 31 (36.5) 63 (47.7)
Comorbidities, n (%)
 Chronic lung diseases 34 (35.4) 40 (27) 0.16
 Diabetes 25 (26) 47 (31.8) 0.34
 Active malignancies 12 (12.5) 47 (31.8) < 0.001*
 Liver disease 7 (7.3) 21 (14.2) 0.10
 Heart failure 14 (14.6) 8 (5.4) 0.01*
 Recent surgery within 3 months. 4 (4.2) 6 (4.1) 1.00
Cause of ARDS, n (%)
 Pneumonia 82 (85.4) 122 (82.4) 0.54
 Aspiration 20 (20.8) 23 (15.5) 0.29
 Non-pulmonary sepsis 6 (6.2) 15 (10.1) 0.29
 Pancreatitis 5 (5.2) 3 (2) 0.27
Echocardiographic findings
 Ejection fraction, median (IQR),% 58.5 (55–64) 60 (55–65) 0.74
 RVSP, median (IQR), mm Hg 39 (32.5–49) 40.5 (31.3–50.8) 0.86
Vasopressors use 66 (68.8) 136 (91.9) < 0.001*
Septic shock 38 (39.6) 104 (70.3) < 0.001*
Nephrotoxic agents 93 (96.9) 142 (95.9) 1.00
Median time to develop AKI 3 (2–6) 4 (2–7) 0.02*
RRT initiation from highest AKI onset 0 (0–0) 0 (0–2) 0.18
Known baseline SCr, n (%) 56 (58.3) 89 (60.1) 0.78
Baseline SCr, mean (SD), mg/dL 0.85 (0.22) 0.8 (0.18) 0.18
eGFR, median (IQR), mL/min per 1.73 m2 92.5 (73.2–109.5) 97.1 (82.2–112.5) 0.10
  1. AKI = acute kidney injury, APACHE = acute physiology, age, chronic health evaluation, ARDS = acute respiratory distress syndrome, eGFR = estimated glomerular filtration rate, IQR = interquartile range, RRT = renal replacement therapy, RVSP = right ventricular systolic pressure, SCr = serum creatinine, SD = standard deviation, SOFA = sequential organ failure assessment
  2. *p < 0.05 when compared with patients with complete renal recovery