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Table 1 Baseline characteristics of all 244 patients by renal recovery

From: Clinical predictors of renal non-recovery in acute respiratory distress syndrome

Characteristic

Recovery (96)

Non-recovery (148)

p value

Age, median (IQR), years

56 (44–66)

56 (43.8–64)

0.57

Male sex, n (%)

55 (57.3)

82 (55.4)

0.77

Body mass index, median (IQR), kg/m2

30.6 (24.5–37.2)

30.2 (25.2–39.4)

0.54

Race, n (%)

 White

70 (72.9)

100 (67.6)

0.37

 Black or African American

25 (26)

33 (22.3)

0.50

SOFA, mean (SD), points

10.6 (3)

12.7 (3.6)

< 0.001*

Non-renal SOFA, mean (SD), points

9.8 (2.7)

11.3 (3)

< 0.001*

APACHE III, mean (SD), points

105 (29)

121 (31)

< 0.001*

Charlson comorbidities index, median (IQR), points

3 (1–5)

3 (1–5)

0.61

Severity of ARDS on day 1

 Mild

13 (15.3)

20 (15.2)

0.22

 Moderate

41 (48.2)

49 (37.1)

 Severe

31 (36.5)

63 (47.7)

Comorbidities, n (%)

 Chronic lung diseases

34 (35.4)

40 (27)

0.16

 Diabetes

25 (26)

47 (31.8)

0.34

 Active malignancies

12 (12.5)

47 (31.8)

< 0.001*

 Liver disease

7 (7.3)

21 (14.2)

0.10

 Heart failure

14 (14.6)

8 (5.4)

0.01*

 Recent surgery within 3 months.

4 (4.2)

6 (4.1)

1.00

Cause of ARDS, n (%)

 Pneumonia

82 (85.4)

122 (82.4)

0.54

 Aspiration

20 (20.8)

23 (15.5)

0.29

 Non-pulmonary sepsis

6 (6.2)

15 (10.1)

0.29

 Pancreatitis

5 (5.2)

3 (2)

0.27

Echocardiographic findings

 Ejection fraction, median (IQR),%

58.5 (55–64)

60 (55–65)

0.74

 RVSP, median (IQR), mm Hg

39 (32.5–49)

40.5 (31.3–50.8)

0.86

Vasopressors use

66 (68.8)

136 (91.9)

< 0.001*

Septic shock

38 (39.6)

104 (70.3)

< 0.001*

Nephrotoxic agents

93 (96.9)

142 (95.9)

1.00

Median time to develop AKI

3 (2–6)

4 (2–7)

0.02*

RRT initiation from highest AKI onset

0 (0–0)

0 (0–2)

0.18

Known baseline SCr, n (%)

56 (58.3)

89 (60.1)

0.78

Baseline SCr, mean (SD), mg/dL

0.85 (0.22)

0.8 (0.18)

0.18

eGFR, median (IQR), mL/min per 1.73 m2

92.5 (73.2–109.5)

97.1 (82.2–112.5)

0.10

  1. AKI = acute kidney injury, APACHE = acute physiology, age, chronic health evaluation, ARDS = acute respiratory distress syndrome, eGFR = estimated glomerular filtration rate, IQR = interquartile range, RRT = renal replacement therapy, RVSP = right ventricular systolic pressure, SCr = serum creatinine, SD = standard deviation, SOFA = sequential organ failure assessment
  2. *p < 0.05 when compared with patients with complete renal recovery
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BMC Nephrology

ISSN: 1471-2369

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