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Table 4 Factors associated with renal non-recovery in patients with acute respiratory distress syndrome

From: Clinical predictors of renal non-recovery in acute respiratory distress syndrome

Variable Univariable analysisa Multivariable analysisb
  OR 95% CI p value OR 95% CI p value
Severity of acute kidney injury
 Stage I Ref Ref Ref Ref Ref Ref
 Stage II 5.00 2.24 to 11.98 < 0.001 5.71 2.17 to 14.98 < 0.001
 Stage III 40.38 17.31 to 103.73 < 0.001 45.85 16.27 to 129.2 < 0.001
Acute kidney injury onset, dayc 1.08 1.02 to 1.16 0.01 1.12 1.03 to 1.21 0.01
SOFA scorec 1.20 1.11 to 1.31 < 0.001
History of heart failure 0.33 0.13 to 0.82 0.02
History of active malignancies 3.26 1.67 to 6.79 < 0.001 4.02 1.59 to 10.15 0.003
Septic shock 3.61 2.12 to 6.24 < 0.001 3.20 1.52 to 6.76 0.002
Mean tidal volume on day 1–3, mL/kg PBWc 1.31 1.08 to 1.61 0.01 1.41 1.05 to 1.90 0.02
Mean PEEP on day 1–3, cm H2Oc 1.06 0.99 to 1.14 0.09
Continuous neuromuscular blocking agents 2.42 1.41 to 4.24 0.002
Inhaled vasodilators 1.95 1.07 to 3.7 0.03
Recruitment maneuvers 4.02 1.31 to 17.58 0.03
Antipsychotic drugs 0.61 0.36 to 1.02 0.06
Furosemide on day 2–7 0.48 0.28 to 0.82 0.01
Fluid overload on day 7, %c 1.07 1.02 to 1.12 0.005
  1. CI = confidence interval, OR = odds ratio, PBW = predicted body weight, Ref = reference
  2. Area under the receiver operating characteristic curve (95% CI) of multivariable analysis = 0.90 (95% CI 0.85–0.94)
  3. aanalysis from non-imputed data
  4. bPool analysis after multivariable logistic regression of 50 imputed data set
  5. cper 1 point increase