Focal segmental glomerulosclerosis, excluding atypical lesion, is a predictor of renal outcome in patients with membranous nephropathy: a retrospective analysis of 716 cases

Table 3 Mutivariate analysis of risk factors for progression to primary outcome– Cox proportional hazards model

Parameters	P value	HR	HR(95% CI)
Model 1:FSGS⁺ and aFSL⁺ groups as one group (FSL⁺ group)
Age ≥ 60 years	0.003	2.602	1.373–4.930
Hypertension	0.127	1.874	0.837–4.192
eGFR< 60(ml/min per 1.73m²)	0.009	2.632	1.279–5.415
FSL (FSGS,aFSL = 1,FSL⁻ = 0)	0.251	1.557	0.731–3.320
Global Glomerulosclerosis (> 5%)	0.278	1.548	0.703–3.410
Proliferation of mesangial (stage1,2,3 = 1)	0.648	1.178	0.582–2.383
Tubulointerstitial fibrosis (area ≥ 15% = 1)	0.003	3.008	1.470–6.156
Vascular sclerosis (stage1,2,3 = 1)	0.267	2.293	0.530–9.921
Moldel 2:FSGS⁺ and aFSL⁺ groups as two individual groups
Age ≥ 60 years	0.001	2.870	1.519–5.424
Hypertension	0.182	1.741	0.771–3.930
eGFR< 60(ml/min per 1.73m²)	0.003	2.925	1.441–5.936
FSL
FSL⁻			1.00 (referent)
FSGS	0.026	2.471	1.113–5.486
aFSL	0.260	0.503	0.152–1.663
Global Glomerulosclerosis (> 5%)	0.338	1.467	0.669–3.215
Proliferation of mesangial (stage 1,2,3 = 1)	0.894	1.049	0.518–2.122
Tubulointerstitial fibrosis (area ≥ 15% = 1)	0.010	2.553	1.248–5.224
Vascular sclerosis (stage 1,2,3 = 1)	0.351	2.014	0.462–8.770

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