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Fig. 5 | BMC Nephrology

Fig. 5

From: Uric acid regulates NLRP3/IL-1β signaling pathway and further induces vascular endothelial cells injury in early CKD through ROS activation and K+ efflux

Fig. 5

UA induced the vascular endothelial injury of early stage CKD by activating NLRP3/IL-1β pathway. a Glomeruli and renal tubule tissues of rats were stained by HE or PAS; b The mRNA expression of ASC, caspase 1, NLRP3, and IL-1β in abdominal aorta and renal tissue was measured by qPCR; c The protein expression of ASC, caspase 1, NLRP3, and IL-1β in abdominal aorta and renal tissue was measured by western blotting; d The vascular injury was investigated through HE staining. *P < 0.05; **p < 0.01; ***p < 0.001.

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BMC Nephrology

ISSN: 1471-2369

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