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Table 3 The comparisons of complement component in the pMN patients with or without anti-PLA2R antibodies

From: Complement activation products in the circulation and urine of primary membranous nephropathy

 

PLA2R-Ab (+) (n = 91)

PLA2R-Ab (−) (n = 43)

Healthy controls

P-C1q

0.8 (0.6–1.1)

0.7 (0.5–0.9)

0.7 (0.5–0.9)

P-C4d

0.2 (0.2–0.3) **

0.2 (0.1–0.2) **

0.02 (0.01–0.02)

P-MBL

19.8 (6.7–38.3)

19.5 (2.5–32.7)

16.3 (6.8–23.8)

P-Bb

0.01 (0.01–0.01) **

0.01 (0.00–0.01) **

0.01 (0.00–0.01)

P-Properdin

0.2 (0.2–0.3)

0.2 (0.1–0.2)

0.2 (0.1–0.3)

P-C3a

79.5 (11.8–118) **

88.1 (10.3–127.8) **

0.9 (0.4–1.5)

P-C5a

3.7 (0.3–23.9) **

1.8 (0.3–23.8) **

0.06 (0.03–0.11)

P-MAC

2.6 (1.6–3.7)

2.3 (1.2–4.0)

2.5 (1.5–3.3)

U-C1q

0.00 (0.00–0.02) **

0.00 (0.00–0.23) **

1.11 (0.04–2.8)

U-C4d

0.05 (0.00–0.89) *

0.02 (0.00–0.019)

0.00 (0.00–0.07)

U-MBL

0.00 (0.00–0.00)

0.0 (0.0–0.0)

0.00 (0.00–0.00)

U-Bb

0.7 (0.0–1.6) **

0.9 (0.2–1.8) **

2.5 (1.7–4.6)

U-Properdin

0.0 (0.0–7.9) *

0.0 (0.0–2.2)

0.0 (0.0–0.0)

U-C3a

12.5 (2.4–36.7) **

21.1 (8.6–42.7) **

3.7 (1.6–5.8)

U-C5a

4.9 (0.0–30.3) *

1.5 (0.0–11.0)

3.3 (1.5–6.5)

U-MAC

0.6 (0.0–2.0) **

0.38 (0.05–3.26) **

0.0 (0.0–0.1)

  1. P plasma, U urine. *: P < 0.05; **: P < 0.01; compared to healthy controls. Data was shown as median (inter-quartile range). No difference was found between the patients with or without anti-PLA2R antibodies (P > 0.05)