Non-adherence to Haemodialysis, Interdialytic weight gain and cardiovascular mortality: a cohort study

BMC Nephrology

Table 4 Cox proportional model hazard for cardiovascular mortality

Risk factors	Unadjusted		Multivariate
Risk factors	HR (CI 95%)	p	HR (CI 95%)	p
Age (years)	1.03 (1.01–1.06)	0.005	1.01 (0.98–1.04)	0.26
Cardiovascular or cerebrovascular disease (yes)	3.48 (1.94–6.24)	< 0.001	3.57 (1.94–6.55)	< 0.001
Diabetes Mellitus (yes)	2.80 (1.53–5.13)	0.001	3.45 (1.80–6.61)	< 0.001
Anuria (yes)	1.53 (0.86–2.74)	0.14	1.52 (0.77–3.00)	0.21
Vascular access (catheter)	2.19 (0.93–5.17)	0.07	2.63 (1.04–6.64)	0.04
Status for kidney transplant (not apt)	3.23 (0.78–13.3)	0.10	1.86 (0.42–8.12)	0.40
Ultrafiltration (ml/h/Kg)	1.05 (0.94–1.17)	0.17	1.05 (0.94–1.17)	0.37
BMI between 18,5–24.9 Kg/m²	1 (reference)	0.16	1 (reference)	0.02
BMI between 25 and 29.9 Kg/m²	1.44 (0.74–2.80)	0.27	1.78 (0.91–3.51)	0.09
BMI ≥ 30 Kg/m²	0.84 (0.25–2.81)	0.78	0.80 (0.23–2.77)	0.73
BMI < 18.5 Kg/m²	2.47 (1.06–5.77)	0.03	3.67 (1.48–9.06)	0.005
% period of HD performed/prescribed (< 100%)	0.63 (0.35–1.13)	0.12	0.86 (0.46–1.63)	0.66
IDWG < 3% of DW	1 (reference)	0.06	1 (reference)	0.005
IDWG 3–3.99% of DW	0.70 (0.30–1.63)	0.42	0.65 (0.27–1.52)	0.32
IDWG ≥4% of DW	1.63 (0.82–3.25)	0.16	2.09 (1.01–4.35)	0.047

HR Hazard ratio, CI confidence interval, BMI body mass index, IDWG interdialytic weight gain, DW dry weight
Other variables assessed in the univariate analysis: sex, race, time on hemodialysis, smoking, systemic arterial hypertension, background of parathyroidectomy, Serum albumin, spKt/V, Parathormone ≥600 pg/mL, Serum phosphorus > 5.5 mg/dL

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