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Table 2 Quality Assessment of Included Studies (7-point)

From: Efficacy and safety of cyclosporine a for patients with steroid-resistant nephrotic syndrome: a meta-analysis

Author, year

Type

Randomization

Concealment of allocation

Double blinding

Withdrawals and dropouts

Jadad score

Ponticelli 1993 (CsA vs. P/NT)

An open, prospective, randomized, multicentric, controlled

study

According to a table of random numbers

By using sealed, completely opaque envelopes

Open-label

Yes

5

Lieberman 1996(CsA vs. P/NT)

A double-blinded, prospectively randomized, placebo-controlled trial

By following computer based random numbers

By using sequentially labelled sealed envelopes

Both the patients and their pediatric

nephroboglsts were blinded as to the administered study

treatment

Yes

7

Plank 2008 (CsA vs. CYC)

A controlled multicentre randomized open label trial

According to centre-specific computer-generated random

lists

Describing as using allocation concealment but without any details

Open-label

Yes

5

Choudhry 2009 (CsA vs. TAC)

A nonblind, randomized controlled trial

By following computer based random numbers

By using serially

numbered opaque envelopes

Open-label

No

5

Garin 2015 (CsA vs. P/NT)

A cross-over, randomized, controlled trial

Describing as a randomized trial without details

NA

NA

NA

1

Geng 2018 (CsA vs. MMF)

A prospective, randomized controlled clinical trial

According to a table of random numbers

NA

NA

Yes

3

  1. Note: CsA cyclosporine A; CTX cyclophosphamide; TAC tacrolimus; MMF mycophenolate mofetil; NA not available