Table 2 Basement membrane proteins identified in our study sorted by fold change between IgAN and control patients. The linear and mesangial matrix staining patterns were assessed by visual inspection of staining in humanproteinatlas.org
Protein Name | Gene Name | Uniprot ID | IgAN total vs control | IgAN progr vs IgA non-progr | Linear GMB staining | Mesangial Matrix staining | ||
|---|---|---|---|---|---|---|---|---|
Fold change | P-value | Fold change | P-value | |||||
Collagen alpha-1(XV) chain | COL15A1 | P39059 | 2.39 | 0.03 | 2.30 | 0.10 | Yes | Yes |
Tenascin | TNC | P24821 | 1.85 | 0.0001 | 1.16 | 0.51 | Yes | Yes |
Collagen alpha-1(IV) chain | COL4A1 | P02462 | 1.54 | 0.000003 | 1.10 | 0.88 | Yes | Yes |
Fibronectin | FN1 | P02751 | 1.50 | 0.00004 | 1.17 | 0.12 | Yes | Yes |
Collagen alpha-2(IV) chain | COL5A2 | P08572 | 1.38 | 0.0003 | 0.99 | 0.76 | Not detected | Not detected |
von Willebrand factor A domain-containing protein 1 | VWA1 | Q6PCB0 | 1.36 | 0.01 | 1.41 | 0.01 | Pending tissue analysis | |
Nidogen-2 | NID2 | Q14112 | 1.33 | 0.0004 | 1.13 | 0.62 | Yes | Yes |
Laminin subunit beta-1 | LAMB1 | P07942 | 1.33 | 0.003 | 1.05 | 0.52 | Yes | Yes |
Basement membrane-specific heparan sulfate proteoglycan core protein | HSPG2 | P98160 | 1.33 | 0.002 | 1.08 | 0.97 | Yes | Yes |
Fibulin-1 | FBLN1 | P23142 | 1.32 | 0.01 | 1.35 | 0.20 | Yes | Yes |