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Table 1 Effect of curcumin treatment on serum lipid profile changes after 24 days in adenine-induced CKD rats

From: Chronic treatment of curcumin improves hepatic lipid metabolism and alleviates the renal damage in adenine-induced chronic kidney disease in Sprague-Dawley rats

Parameter Normal
Control
CKD
Control
CUR
(50 mg/kg)
CUR
(100 mg/kg)
CUR
(150 mg/kg)
Total cholesterol (mg/dL) 82.11 ± 8.38 153.28 ± 4.64### 102.46 ± 11.09** 84.74 ± 3.91*** 106.22 ± 13.52**
Triglycerides (mg/dL) 68.59 ± 3.82 109.19 ± 1.71### 85.42 ± 3.09* 65.65 ± 6.37*** 75.70 ± 6.19**
HDL-cholesterol (mg/dL) 35.42 ± 3.10 16.16 ± 3.33### 23.44 ± 1.11ns 29.74 ± 1.11* 28.36 ± 3.41*
LDL-cholesterol (mg/dL) 32.97 ± 14.41 115.28 ± 5.23### 54.81 ± 5.35*** 44.42 ± 4.28*** 46.11 ± 4.09***
VLDL-cholesterol (mg/dL) 13.72 ± 0.76 21.84 ± 0.34### 17.08 ± 0.62* 13.13 ± 1.28*** 15.14 ± 1.24**
NEFA (μEq/L) 872.63 ± 18.03 1099.16 ± 16.36# 810.92 ± 60.81ns 760.55 ± 37.07* 734.97 ± 78.61**
AI 1.31 ± 0.17 10.63 ± 2.28### 3.41 ± 0.48*** 2.22 ± 0.58*** 3.26 ± 1.17***
CRI 2.31 ± 0.17 11.63 ± 2.28### 4.41 ± 0.5*** 3.22 ± 0.2*** 3.10 ± 0.1****
  1. Values represent the mean ± SEM of 5 to 6 rats
  2. Significant difference from normal control: #p < 0.05; ###p < 0.001
  3. Significant difference from CKD control: *p < 0.05; **p < 0.01; ***p < 0.001
  4. No significant difference from CKD control: ns (p > 0.05)
  5. CKD Chronic kidney disease; CUR Curcumin; NEFA Non-esterified free fatty acids
  6. AI Atherogenic index; CRI Coronary risk index