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Table 1 Effect of curcumin treatment on serum lipid profile changes after 24 days in adenine-induced CKD rats

From: Chronic treatment of curcumin improves hepatic lipid metabolism and alleviates the renal damage in adenine-induced chronic kidney disease in Sprague-Dawley rats

Parameter

Normal

Control

CKD

Control

CUR

(50 mg/kg)

CUR

(100 mg/kg)

CUR

(150 mg/kg)

Total cholesterol (mg/dL)

82.11 ± 8.38

153.28 ± 4.64###

102.46 ± 11.09**

84.74 ± 3.91***

106.22 ± 13.52**

Triglycerides (mg/dL)

68.59 ± 3.82

109.19 ± 1.71###

85.42 ± 3.09*

65.65 ± 6.37***

75.70 ± 6.19**

HDL-cholesterol (mg/dL)

35.42 ± 3.10

16.16 ± 3.33###

23.44 ± 1.11ns

29.74 ± 1.11*

28.36 ± 3.41*

LDL-cholesterol (mg/dL)

32.97 ± 14.41

115.28 ± 5.23###

54.81 ± 5.35***

44.42 ± 4.28***

46.11 ± 4.09***

VLDL-cholesterol (mg/dL)

13.72 ± 0.76

21.84 ± 0.34###

17.08 ± 0.62*

13.13 ± 1.28***

15.14 ± 1.24**

NEFA (μEq/L)

872.63 ± 18.03

1099.16 ± 16.36#

810.92 ± 60.81ns

760.55 ± 37.07*

734.97 ± 78.61**

AI

1.31 ± 0.17

10.63 ± 2.28###

3.41 ± 0.48***

2.22 ± 0.58***

3.26 ± 1.17***

CRI

2.31 ± 0.17

11.63 ± 2.28###

4.41 ± 0.5***

3.22 ± 0.2***

3.10 ± 0.1****

  1. Values represent the mean ± SEM of 5 to 6 rats
  2. Significant difference from normal control: #p < 0.05; ###p < 0.001
  3. Significant difference from CKD control: *p < 0.05; **p < 0.01; ***p < 0.001
  4. No significant difference from CKD control: ns (p > 0.05)
  5. CKD Chronic kidney disease; CUR Curcumin; NEFA Non-esterified free fatty acids
  6. AI Atherogenic index; CRI Coronary risk index
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BMC Nephrology

ISSN: 1471-2369

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