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Table 2 Effect of curcumin treatment for 24 days on serum and urine biomarkers of renal function in adenine-induced CKD rats

From: Chronic treatment of curcumin improves hepatic lipid metabolism and alleviates the renal damage in adenine-induced chronic kidney disease in Sprague-Dawley rats

Biologic

Fluid

Biomarker

Normal

Control

CKD

Control

CUR

(50 mg/kg)

CUR

(100 mg/kg)

CUR

(150 mg/kg)

Serum

 

Creatinine (mg/dL)

0.45 ± 0.07

2.62 ± 0.08###

2.50 ± 0.15ns

1.71 ± 0.10**

1.27 ± 0.48**

BUN (mg/dL)

4.46 ± 1.53

13.09 ± 1.19##

12.49 ± 2.53 ns

7.14 ± 1.60*

4.99 ± 1.30**

Albumin (mg/dL)

8.41 ± 0.32

5.47 ± 0.08###

6.57 ± 0.27 ns

7.06 ± 0.39**

6.45 ± 0.27*

Urine

 

Urine volume (mL)

24.40 ± 2.21

37.00 ± 1.58###

32.50 ± 0.92

28.58 ± 1.46***

25.67 ± 1.17***

Total protein (mg/24 h)

5.52 ± 0.83

70.73 ± 4.14###

25.26 ± 3.07***

14.82 ± 3.33***

18.13 ± 2.46***

Creatinine (mg/dL)

28.69 ± 2.61

11.23 ± 0.34###

13.54 ± 0.85 ns

22.72 ± 1.31***

23.56 ± 2.15***

UUN (mg/dL)

14.28 ± 1.06

5.95 ± 0.75###

8.92 ± 0.82ns

9.96 ± 0.65**

10.01 ± 0.25**

CrCl (mL/min/kg)

3.07 ± 0.20

0.63 ± 0.13###

0.53 ± 0.05 ns

1.37 ± 0.15*

2.03 ± 0.23***

  1. Values represent the mean ± SEM of 5 to 6 rats
  2. Significant difference from normal control: ##p < 0.01; ###p < 0.001
  3. Significant difference from CKD control: *p < 0.05; **p < 0.01; ***p < 0.001
  4. No significant difference from CKD control: ns (p > 0.05)
  5. CKD Chronic kidney disease; CUR Curcumin; BUN Blood urea nitrogen; CrCl Creatinine clearance; UUN Urine urea nitrogen