Biologic Fluid | Biomarker | Normal Control | CKD Control | CUR (50 mg/kg) | CUR (100 mg/kg) | CUR (150 mg/kg) |
---|---|---|---|---|---|---|
Serum | ||||||
 | Creatinine (mg/dL) | 0.45 ± 0.07 | 2.62 ± 0.08### | 2.50 ± 0.15ns | 1.71 ± 0.10** | 1.27 ± 0.48** |
BUN (mg/dL) | 4.46 ± 1.53 | 13.09 ± 1.19## | 12.49 ± 2.53 ns | 7.14 ± 1.60* | 4.99 ± 1.30** | |
Albumin (mg/dL) | 8.41 ± 0.32 | 5.47 ± 0.08### | 6.57 ± 0.27 ns | 7.06 ± 0.39** | 6.45 ± 0.27* | |
Urine | ||||||
 | Urine volume (mL) | 24.40 ± 2.21 | 37.00 ± 1.58### | 32.50 ± 0.92 | 28.58 ± 1.46*** | 25.67 ± 1.17*** |
Total protein (mg/24 h) | 5.52 ± 0.83 | 70.73 ± 4.14### | 25.26 ± 3.07*** | 14.82 ± 3.33*** | 18.13 ± 2.46*** | |
Creatinine (mg/dL) | 28.69 ± 2.61 | 11.23 ± 0.34### | 13.54 ± 0.85 ns | 22.72 ± 1.31*** | 23.56 ± 2.15*** | |
UUN (mg/dL) | 14.28 ± 1.06 | 5.95 ± 0.75### | 8.92 ± 0.82ns | 9.96 ± 0.65** | 10.01 ± 0.25** | |
CrCl (mL/min/kg) | 3.07 ± 0.20 | 0.63 ± 0.13### | 0.53 ± 0.05 ns | 1.37 ± 0.15* | 2.03 ± 0.23*** |