A comparison between the combined effect of calcium carbonate with sucroferric oxyhydroxide and other phosphate binders: an in vitro and in vivo experimental study

Table 4 Measured phosphate-binding capacity of coadministered calcium carbonate and each phosphate binder

Drugs	Phosphate-binding capacity (mg phosphate/g ingredient)
Drugs	CC + PA21	CC + LC	CC + SH	CC + FC
pH 2	671 ± 81	799 ± 15	411 ± 25	26 ± 4
pH 3	625 ± 32	535 ± 29	471 ± 15	ND
pH 4	640 ± 11	579 ± 10	410 ± 1	11 ± 7
pH 5	684 ± 23	579 ± 24	401 ± 14	58
pH 6	544 ± 19	410 ± 11	405 ± 3	19
pH 7	446 ± 13	214 ± 25	357 ± 4	26 ± 12
pH 8	167 ± 3	157 ± 11	251 ± 6	24 ± 2

Each value shows the mean value ± standard error of three cases (two cases for CC + FC at pH 2, ND for CC + FC at pH 3, two cases for CC + FC at pH 4, one case for CC + FC at pH 5, and one case for CC + FC at pH 6 as no adsorption was observed in any or all cases). CC Calcium carbonate, LC Lanthanum carbonate hydrate, SH Sevelamer hydrochloride, FC Ferric citrate hydrate, ND Not detected

ISSN: 1471-2369