Case report: increased single-nephron estimated glomerular filtration rate in an adult patient with low birth weight

Table 1 Detailed morphometric characteristics and comparison with the other two studies

Characteristics	This study	Living kidney donors (93–94% Caucasian)	Living kidney donors (100% Japanese)^***
Kidney function
eGFR_cys (ml/min)	41.86	Total GFR: 127 ± 25 ml/min^*	eGFR_cr: 76 ± 12 mL/min/1.73 m²
eGFR_cr-cys (ml/min)	45.61
eGFR_cr (ml/min)	47.19
Morphometric measurements
Renal parenchymal volume per kidney (cm³)	90.15		124 ± 24
Renal cortical volume per kidney (cm³)	69.25		89 ± 19
Cortical area in biopsy specimen (mm²)	8.62		2.96 ± 0.79
Glomerular volume (× 10⁶ μm³)	7.16		2.44 ± 1.04
Glomerular density (/mm³)	1.33		2.42 ± 0.67
Non-sclerotic nephron number per kidney	208,000		650,000 ± 220,000
% Globally sclerotic glomeruli	20%	1.1 (0.8–1.5)^**	4.7 (0–35.3)
Total nephron number per kidney	265,000	970,000 ± 430,000^*	710,000 ± 220,000
Calculated nephron-related values
Single-nephron eGFR_cys (nl/min)	101	Single-Nephron GFR: 79 ± 42 nl/min^*
Single-nephron eGFR_cr-cys (nl/min)	110
Single-nephron eGFR_cr (nl/min)	113

eGFR_cys with body surface area (BSA) adjustment calculated by the cystatin C level using CKD-EPI_cys, and eGFR_cr-cys with BSA adjustment calculated by both the creatinine and cystatin C levels using CKD-EPI_cr-cys with the coefficient modification using the Japanese eq. (0.908 ×) [11]. eGFR_cr with BSA adjustment calculated by the creatinine level using the equation for the Japanese population [10]. eGFR_cys, eGFR_cr-cys, and eGFR_cr are individualized without BSA adjustment. Single-nephron eGFR_cys, eGFR_cr-cys, and eGFR_cr are calculated from the individualized eGFR_cys, eGFR_cr-cys, and eGFR_cr, respectively
^*The data of the same age group (18–29 years) in the healthy living kidney donors (93.7% Caucasian) [7]
^**The data of the same age group (18–29 years) in the healthy living kidney donors (92.7% Caucasian) [12]
^***The data in the healthy living kidney donors (100% Japanese, 56.7 ± 9.5 years) [13]

ISSN: 1471-2369