Skip to main content

Table 1 Clinical and hemodialysis parameters of study patients

From: High dose haemodialysis and haemodiafiltration parameters and the relationship with advanced vascular calcification

 

All (n = 297)

No VC (n = 32)

Mild VC (n = 131)

Advanced VC (n = 134)

P value

Age (years)

62.7 ± 12.8

52.5 ± 14.6

61.2 ± 12.5

66.5 ± 10.9

0.000

Body mass index, (Kg/m2)

23.1 ± 3.9

25.4 ± 5.1

22.7 ± 3.3

22.9 ± 3.9

0.001

Male gender

210 (70.7%)

0

113 (53.8%)

97 (46.2%)

0.609

Comorbidities

 Diabetes

56.6

15 (46.9%)

65 (49.6%)

88 (65.7%)

0.016

 Hypertension

87.2

29 (90.6%)

113 (86.3%)

117 (87.3%)

0.802

 CAD

20.3

3 (9.4%)

17 (13.0%)

39 (29.1%)

0.001

 CVD

24.2

2 (6.3%)

28 (21.4%)

41 (30.6%)

0.010

Charlson’s comorbidity index

4.1 ± 1.5

3.3 ± 1.3

4.0 ± 1.7

4.5 ± 1.3

0.000

Dialysis duration (months)

81.5 ± 73.5

51.4 ± 29.9

73.5 ± 66.0

93.3 ± 79.8

0.010

Dialysis mode

    

0.000

 Haemodilaysis

220 (74.1%)

26 (81.3%)

110 (84.0%)

84 (62.7%)

 

 Haemodiafiltration

77 (25.9%)

6 (18.8%)

21 (16.0%)

50 (37.3%)

 

Single pool Kt/V

1.55 ± 0.29

1.39 ± 0.30

1.51 ± 0.29

1.64 ± 0.27

0.000

Equilibrated Kt/V

1.35 ± 0.25

1.21 ± 0.25

1.31 ± 0.25

1.42 ± 0.23

0.000

Standard Kt/V

2.20 ± 0.20

2.08 ± 0.21

2.17 ± 0.20

2.26 ± 0.18

0.000

Urea reduction ratio (%)

72.6 ± 6.9

68.6 ± 7.2

71.6 ± 6.9

74.5 ± 6.2

0.000

Blood flow rate (ml/min)

265.5 ± 23.3

263.4 ± 15.6

260.8 ± 22.8

270.4 ± 24.3

0.003

Cinacalcet administration

21 (7.1%)

2 (6.3%)

6 (4.6%)

13 (9.7%)

0.214

Duration of HD (hours)

3.93 ± 0.19

3.95 ± 0.22

3.93 ± 0.17

3.94 ± 0.19

0.891

Pre-dialysis systolic BP (mmHg)

143.6 ± 19.8

143.8 ± 23.5

142.3 ± 21.3

144.8 ± 17.4

0.591

Pre-dialysis diastolic BP (mmHg)

73.3 ± 13.0

75.4 ± 11.4

73.2 ± 13.0

72.9 ± 13.4

0.606

Average UF per session (Kg)

2.2 ± 1.1

2.2 ± 1.3

2.2 ± 1.1

2.2 ± 0.9

0.930

Dry body weight (Kg)

62.8 ± 12.6

71.9 ± 18.3

62.2 ± 11.2

61.2 ± 11.8

0.000

Dialysate sodium (mEq/L)

137.0 ± 2.5

137.5 ± 2.5

137.4 ± 2.5

136.6 ± 2.3

0.012

Dialysate calcium (mEq/L)

2.8 ± 0.4

2.7 ± 0.4

2.8 ± 0.4

2.8 ± 0.4

0.415

Sodium (mmol/L)

137.6 ± 3.4

138.1 ± 3.0

138.4 ± 3.0

136.6 ± 3.7

0.000

Chloride (mmol/L)

99.2 ± 4.9

100.6 ± 3.7

100.3 ± 4.2

97.7 ± 4.9

0.000

Potassium (mmol/L)

4.8 ± 0.7

4.7 ± 0.8

4.7 ± 0.7

4.9 ± 0.8

0.169

Corrected Calcium (mg/dL)

8.6 ± 0.8

8.3 ± 0.7

8.5 ± 0.8

8.7 ± 0.8

0.009

Phosphate (mg/dL)

4.8 ± 1.4

4.8 ± 1.2

4.8 ± 1.6

4.7 ± 1.2

0.830

Total CO2 (mmol/L)

23.9 ± 3.1

23.7 ± 3.0

23.2 ± 3.4

24.5 ± 2.7

0.003

Serum albumin (mg/dL)

3.8 ± 0.4

3.8 ± 0.4

3.8 ± 0.3

3.7 ± 0.4

0.108

MAMC (cm)

22.9 ± 4.9

23.1 ± 6.9

23.0 ± 5.1

22.8 ± 4.6

0.941

nPCR (g/Kg/day)

1.0 ± 0.2

1.03 ± 0.20

1.03 ± 0.23

1.02 ± 0.25

0.918

Intact PTH (pg/mL)

269.7 ± 208.0

275.4 ± 276.6

258.6 ± 184.4

279.2 ± 212.2

0.715

Bone specific ALP (μg/L)

18.9 ± 10.9

14.8 ± 7.9

20.6 ± 12.6

18.3 ± 9.7

0.049

25(OH) Vitamin D (ng/mL)

16.4 ± 10.1

15.6 ± 8.7

16.2 ± 10.0

16.8 ± 10.6

0.807

hsCRP (mg/L)

7.0 ± 13.3

11.7 ± 20.3

7.2 ± 14.1

5.8 ± 9.7

0.081

Average hand grip strength test (Kg)

23.0 ± 10.3

29.0 ± 11.1

24.7 ± 9.9

19.3 ± 9.1

0.000

Vitamin D use

79 (26.6)

13 (40.6)

36 (27.5%)

30 (22.4%)

0.106

Statin use

143 (48.1%)

12 (37.5%)

61 (46.6%)

70 (52.2%)

0.289

Warfarin use

7 (2.4%)

0

1 (0.8%)

6 (4.5%)

0.089

  1. Data are expressed as mean ± SD for continuous variables
  2. VC Vascular calcification, CADL Coronary artery disease, CVD Cerebrovascular disease, UF Ultrafiltration, MAMC Mid-arm muscle circumference, nPCR Normalized protein catabolic rate, SGA Subject global assessment, PTH Parathyroid hormone, ALP Alkaline phosphatase, CRP C-reactive protein