Table 1 Patients characteristics according to presence of active MM diagnosis. Median creatinine and estimated glomerular filtration rate are not different in both groups. Median κ, λ sFLC and sFLC ratio present statistically significant differences (p < 0.01), with higher Kappa and sFLC ratio in patients with active MM . Surprisingly, lambda is increased in the group without MM in comparison with the active MM group, probably because of the higher incidence of Kappa light chain isotype in the MM group. The sFLC ratio corrects this fact
Variables | All patients (n = 523) | Patients with active MM (n = 347) | Patients without active MM (n = 176) | P-value |
|---|---|---|---|---|
Median eGFR (IQR) | 85 (62–91) | 84(60–91) | 86 (65–91) | 0,314 |
Creatinine (mg/dl) (IQR) | 0,83 (0,67-1,1) | 0,84 (0,66-1,12) | 0,82 (0,68-1,07) | 0,854 |
MM Type | ||||
IgG (%) | 198 (57) | |||
IgA (%) | 88 (25,4) | |||
IgM (%) | 6 (1,7) | |||
IgD (%) | 4 (1,1) | |||
IgG + IgA (%) | 6 (1,7) | |||
Bence-Jones (%) | 44 (12,7) | |||
Non-secretory (%) | 1 (0,3) | |||
FLC type | ||||
Κ sFLC (%) | 227 (65,4) | |||
λ sFLC (%) | 114 (32,8) | |||
Κ + λ sFLC (%) | 5 (1,4) | |||
Non-secretory (%) | 1 (0,3) | |||
FLC level (mg/L) | ||||
Median k sFLC (IQR) | 21,1 (11,5-65,4) | 26,4 (10,9–147) | 17,35 (12,27-32,12) | < 0.001 |
Median λ sFLC (IQR) | 13,8 (7,5-28,6) | 11,2 (6,2-30,4) | 16,4 (11,5-26,47) | 0,001 |
Median sFLC ratio (IQR) | 1,34 (0,77-6,24) | 2,5 (0,49-17,65) | 1,11 (0,89-1,39) | < 0.001 |