Accuracy and concordance of measurement methods to assess non-adherence after renal transplantation - a prospective study

Lieb, Marietta; Hepp, Tobias; Schiffer, Mario; Opgenoorth, Mirian; Erim, Yesim

doi:10.1186/s12882-020-01781-1

Table 5 Linear and piecewise linear mixed models on the change of adherence over time

From: Accuracy and concordance of measurement methods to assess non-adherence after renal transplantation - a prospective study

Variable	Model	Parameter	Estimate (CI)	SE	z-value	p-value
TA – Electronic monitoring	LMM – with linear trend	Intercept Time	5.05 (3.32, 6.77)	0.88	5.74	<.001**
TA – Electronic monitoring	LMM – with linear trend	Intercept Time	−0.41 (− 0.65, − 0.172)	0.12	−3.38	<.001**
	LMM – with piecewise linear trend	Intercept	4.16 (2.49, 5.82)	0.85	4.90	<.001**
		Time ≥ T2	0.77 (−0.86, 2.40)	0.83	0.93	0.35
		Time ≥ T3	−1.13 (−2.72, 0.47)	0.81	−1.38	0.17
		Time ≥ T4	−0.01 (−1.31, 1.30)	0.67	− 0.01	0.99
		Time ≥ T5	−0.81 (− 2.07, 0.45)	0.64	1.26	0.21
		Time ≥ T6	−0.49 (− 1.61, 0.62)	0.57	− 0.87	0.39
TM ±2 h – Electronic monitoring	LMM – with linear trend	Intercept	3.21 (2.26, 4.15)	0.48	6.64	<.001**
TM ±2 h – Electronic monitoring	LMM – with linear trend	Time	−0.37 (− 0.55, − 0.20)	0.09	−4.13	<.001**
	LMM – with piecewise linear trend	Intercept	2.44 (1.51, 3.37)	0.47	5.17	<.001**
		Time ≥ T2	0.58 (−0.53, 1.70)	0.57	1.03	0.31
		Time ≥ T3	−0.96 (−2.06, 0.14)	0.56	−1.71	0.09
		Time ≥ T4	−0.25 (− 1.20, 0.71)	0.48	−0.50	0.61
		Time ≥ T5	−0.47 (−1.41, 0.47)	0.48	−0.97	0.33
		Time ≥ T6	−0.48 (−1.39, 0.43)	0.46	− 1.02	0.31
TM ±30 min – Electronic monitoring	LMM – with linear trend	Intercept	0.91 (0.15, 1.68)	0.39	2.35	<.05*
TM ±30 min – Electronic monitoring	LMM – with linear trend	Time	−0.26 (− 0.41, − 0.11)	0.08	−3.38	<.001**
	LMM – with piecewise linear trend	Intercept	0.76 (−0.04, 1.56)	0.41	0.41	0.06
		Time ≥ T2	−0.29 (−1.15,0.56)	0.44	0.44	0.50
		Time ≥ T3	−0.22 (−1.07, 0.63)	0.43	0.43	0.61
		Time ≥ T4	−0.79 (−1.64, 0.06)	0.43	0.43	0.07
		Time ≥ T5	−0.13 (− 0.99, 0.74)	0.44	0.44	0.77
		Time ≥ T6	0.45 (− 0.43, 1.33)	0.45	1.01	0.31
Variable	Model	Parameter	Estimate (CI)	SE	t-value	Sign.
Intervention effect – self-assessment	LMM – with linear trend	Intercept	1.81 (1.01, 2.62)	0.41	4.43	<.05*
Intervention effect – self-assessment	LMM – with linear trend	Time	0.02 (−0.10, 0.13)	0.06	0.29	ns
	LMM – with piecewise linear trend	Intercept	1.95 (1.13, 2.77)	0.42	4.66	<.05*
		Time ≥ T2	−0.14 (−0.82, 0.55)	0.35	−0.39	ns
		Time ≥ T3	−0.05 (− 0.74, 0.65)	0.35	− 0.13	ns
		Time ≥ T4	−0.15 (− 0.55, 0.85)	0.36	0.41	ns
		Time ≥ T5	−0.20 (− 0.90, 0.50)	0.36	− 0.56	ns
		Time ≥ T6	0.40 (−0.30, 1.10)	0.36	1.12	ns

Note: ** < .001, * p < .05, TA = Taking Adherence, TM + -2 h = Timing Adherence + − 2 h, TM + -30 min = Timing Adherence, LMM = Linear Mixed Model, ns = not significant

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