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Table 3 Multivariate Cox regression analysis of stroke and composite endpoints

From: Effects of parathyroid hormone and vitamin D supplementation on stroke among patients receiving peritoneal dialysis

Variables

Model 1

Model 2

HR [95% CI]

p-value

HR [95% CI]

p-value

Age (years)

1.03 [0.99, 1.06]

0.1

1.03 [1.01, 1.06]

0.008

Gender (male)

  

1.53 [1.04, 2.25]

0.03

Serum albumin (g/l)

0.99 [0.94, 1.05]

0.7

0.99 [0.95, 1.03]

0.6

Serum UA (mg/dl)

1.06 [0.91, 1.24]

0.4

0.99 [0.90, 1.08]

0.8

Serum calcium (mmol/l)

1.07 [0.31, 3.63]

0.9

1.13 [0.51, 2.52]

0.8

Serum phosphorus (mmol/l)

1.08 [0.52, 2.24]

0.8

1.11 [0.69, 1.81]

0.7

iPTH levels

  ≤ 150

Ref

–

Ref

–

 150–300

0.02 [0.00, 0.89]

0.04

0.48 [0.06, 3.59]

0.5

 300–600

0.21 [0.01, 5.18]

0.3

0.22 [0.03, 1.77]

0.2

  > 600

0.50 [0.00, 51.58]

0.8

0.33 [0.02, 5.29]

0.4

SBP (mmHg)

1.01 [1.00, 1.02]

0.06

1.00 [0.99, 1.01]

0.9

DBP (mmHg)

0.98 [0.96, 1.00]

0.04

1.00 [0.99, 1.02]

0.8

Chronic heart disease (yes)

  

2.34 [1.60, 3.43]

< 0.001

Atrial fibrillation (yes)

1.27 [0.48, 3.33]

0.6

1.16 [0.56, 2.40]

0.7

Diabetes (yes)

1.31 [0.73, 2.36]

0.4

1.53 [1.04, 2.26]

0.03

Vitamin D (yes)

0.42 [0.23, 0.76]

0.004

0.50 [0.33, 0.74]

0.001

Antiplatelet agents (yes)

1.72 [0.93, 3.15]

0.08

0.84 [0.57, 1.23]

0.4

Anticoagulants (yes)

  

0.94 [0.34, 2.63]

0.9

Calcium agents (yes)

0.49 [0.27, 0.89]

0.02

0.79 [0.51, 1.23]

0.3

Interaction term

 Age: iPTH < 150

Ref

–

Ref

–

 Age: iPTH 150–300

1.06 [1.00, 1.13]

0.06

1.01 [0.98, 1.05]

0.5

 Age: iPTH 300–600

1.02 [0.97, 1.07]

0.5

1.02 [0.98, 1.06]

0.3

 Age: iPTH > 600

1.02 [0.93, 1.11]

0.7

1.03 [0.97, 1.08]

0.3

  1. Variables with a p-value less than 0.1 in the univariate Cox regression analyses were selected to build the multivariate Cox regression models. Model 1: multivariate model for stroke; Model 2: multivariate model for composite endpoints