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Fig. 1 | BMC Nephrology

Fig. 1

From: Brilliant blue G, a P2X7 receptor antagonist, attenuates early phase of renal inflammation, interstitial fibrosis and is associated with renal cell proliferation in ureteral obstruction in rats

Fig. 1

BBG administration decreases P2X7-R immunoexpression in tubular cortex but not in medulla in UUO. a Graphical representation of P2X7 surface density in tubular cells in renal cortex. The graphic shows aligned dot plot and the mean ± SEM of 20 captured images of each animal kidney in the different experimental groups. * p < 0.05 vs UUO-BBG and both SHAM groups. # p < 0.05 vs UUO-V and both SHAM groups. b Representative immunostaining of the renal cortex from UUO-V group. The arrows indicate one immunostained interstitial cell. c UUO-BBG group. d Graphical representation of P2X7 surface density in tubular cells in renal medulla. The graphic shows aligned dot plot and the mean ± SEM of 20 captured images of each animal kidney in the different experimental groups. * p < 0.05 vs both SHAM groups, but not between UUO groups. Representative immunostaining of the renal medulla from (e) UUO-V group and (f) UUO-BBG group. All pictures of the sham control groups are shown in the supplementary material. Bar = 50 μm in all figures.

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