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Table 2 Multiple regression analysis of log-transformed urinary protein levels at renal biopsy and histological variables

From: Association of explanatory histological findings and urinary protein and serum creatinine levels at renal biopsy in lupus nephritis: a cross-sectional study

VariableModel 1Model 2Model 3
Coeff [95% CI]Coeff [95% CI]Coeff [95% CI]
Active lesions
 Endocapillary proliferation0.66 [− 0.12 to 1.44]0.64 [− 0.13 to 1.41]0.67 [− 0.10 to 1.43]
 Karyorrhexis0.93 [−2.11 to 3.97]0.87 [− 1.14 to 2.87]0.84 [− 1.16 to 2.83]
 Fibrinoid necrosis−0.12 [− 2.82 to 2.58]  
 Rupture of glomerular basement membranes2.34 [−5.52 to 10.21]2.26 [−4.48 to 9.00]2.14 [−4.60 to 8.87]
 Extracapillary proliferation1.79 [−0.63 to 4.22]1.77 [−0.62 to 4.16]1.84 [− 0.54 to 4.22]
 Wire loop lesions1.08 [0.33 to 1.82]1.09 [0.35 to 1.83]1.00 [0.28 to 1.71]
 Hyaline deposits1.18 [−2.65 to 5.00]1.12 [−2.65 to 4.89]1.39 [− 2.34 to 5.12]
 Membranous lesions0.64 [−0.07 to 1.35]0.67 [− 0.02 to 1.35]0.67 [− 0.01 to 1.36]
 Monocellular infiltration
(category)
− 0.25 [− 1.48 to 0.98] − 0.07 [− 0.53 to 0.39]
Chronic lesions
 Glomerular sclerosis1.13 [− 0.28 to 2.54]1.15 [− 0.24 to 2.54]1.13 [− 0.24 to 2.49]
 Fibrous adhesion− 0.40 [− 3.41 to 2.62]−0.35 [− 3.33 to 2.63]−0.25 [− 3.21 to 2.71]
 Fibrous crescents1.63 [− 3.93 to 7.19]1.60 [− 3.76 to 6.95]1.80 [− 3.56 to 7.15]
 Interstitial fibrosis (category)0.23 [− 1.01 to 1.47]0.00 [− 0.47 to 0.47] 
 Arteriosclerosis (category)0.15 [− 0.38 to 0.68]0.13 [− 0.39 to 0.64]0.17 [− 0.35 to 0.68]
  1. Proteinuria was log-transformed to obtain a closer approximation to normal distribution. Covariates; Model 1: all independent explanatory variables; Model 2: explanatory variables excluding fibrinoid necrosis and monocellular infiltration; Model 3: explanatory variables excluding fibrinoid necrosis and interstitial fibrosis. Coeff β-Coefficient; CI Confidential interval