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Table 3 Multiple regression analysis of serum creatinine levels at renal biopsy and histological variables

From: Association of explanatory histological findings and urinary protein and serum creatinine levels at renal biopsy in lupus nephritis: a cross-sectional study

VariableModel 1Model 2Model 3
Coeff [95% CI]Coeff [95% CI]Coeff [95% CI]
Active lesions
 Endocapillary proliferation0.15 [− 0.22 to 0.51]0.16 [− 0.20 to 0.52]0.16 [− 0.2 to 0.52]
 Karyorrhexis0.08 [− 1.34 to 1.51]0.20 [− 0.74 to 1.15]0.23 [− 0.71 to 1.17]
 Fibrinoid necrosis0.18 [− 1.08 to 1.45]  
 Rupture of glomerular
basement membranes
0.16 [− 3.54 to 3.85]0.34 [− 2.83 to 3.52]0.39 [− 2.79 to 3.56]
 Extracapillary proliferation0.37 [− 0.77 to 1.51]0.40 [− 0.73 to 1.52]0.42 [− 0.7 to 1.54]
 Wire loop lesions0.13 [− 0.22 to 0.48]0.12 [− 0.22 to 0.47]0.08 [− 0.26 to 0.42]
 Hyaline deposits−1.84 [− 3.64 to − 0.04]− 1.78 [− 3.56 to − 0.00]− 1.67 [− 3.43 to 0.09]
 Membranous lesions−0.17 [− 0.50 to 0.17]−0.19 [− 0.51 to 0.13]−0.15 [− 0.48 to 0.17]
 Monocellular infiltration (category)0.22 [− 0.36 to 0.80] 0.26 [0.04 to 0.47]
Chronic lesions
 Glomerular sclerosis1.10 [0.43 to 1.76]1.08 [0.43 to 1.74]1.07 [0.43 to 1.72]
 Fibrous adhesion0.73 [−0.69 to 2.14]0.68 [−0.72 to 2.08]0.79 [− 0.61 to 2.19]
 Fibrous crescents−1.30 [− 3.91 to 1.31]−1.31 [− 3.84 to 1.21]− 1.32 [− 3.84 to 1.21]
 Interstitial fibrosis (category)0.06 [− 0.52 to 0.65]0.27 [0.05 to 0.49] 
 Arteriosclerosis (category)− 0.04 [− 0.29 to 0.21]−0.02 [− 0.26 to 0.23]− 0.02 [− 0.26 to 0.23]
  1. Covariates; Model 1: all independent explanatory variables; Model 2: explanatory variables excluding fibrinoid necrosis and monocellular infiltration; Model 3: explanatory variables excluding fibrinoid necrosis and interstitial fibrosis. Coeff β-Coefficient; CI Confidential interval
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