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Table 1 Baseline demographic and clinical data in the patients with and without AKD

From: Acute kidney disease and acute kidney injury biomarkers in coronary care unit patients

 All Patients (n = 269)AKD (n = 128)Non-AKD
(n = 141)
p-value
Demographic and clinical variables
 Age (years)64 ± 168 ± 161 ± 1< 0.001
 Gender, Male(%)202(75)97(76)105(74)NS(0.888)
 Body weight (kg)66.3 ± 0.865.2 ± 1.167.4 ± 1.0NS(0.157)
 Diabetes mellitus, n(%)110(41)58(45)52(37)NS(0.173)
 Hypertension, n(%)163(61)85(66)78(55)NS(0.08)
 Sepsis, n(%)15(5.6)15(12)0(0)0.001
 Body temperature (°C)36.9 ± 0.137.1 ± 0.136.8 ± 0.10.026
 Respiratory rate(/min)22 ± 023 ± 121 ± 0< 0.001
 Mean arterial pressure (mmHg)90 ± 392 ± 789 ± 1NS(0.608)
 Blood sugar (mg/dl)160 ± 5166 ± 9155 ± 6NS(0.288)
AKI biomarkers
 Serum IL-18 (ng/ml)350 ± 20454 ± 36256 ± 15< 0.001
 Urine IL-18 (ng/ml)61 ± 264 ± 359 ± 2NS(0.165)
 Serum NGAL (ng/ml)112 ± 9138 ± 1488 ± 100.004
 Urine NGAL (ng/ml)46 ± 1077 ± 2020 ± 40.007
 Serum CysC (mg/L)1.9 ± 0.12.4 ± 0.21.5 ± 0.10.001
 Urine CysC (mg/L)1.0 ± 0.51.8 ± 1.10.4 ± 0.2NS(0.213)
Other Laboratory examinations
 Serum creatinine baseline (mg/dL)1.36 ± 0.071.44 ± 0.091.15 ± 0.100.029
 Serum creatinine 0–24 h (mg/dL)1.64 ± 0.131.96 ± 0.181.07 ± 0.14< 0.001
 Serum creatinine 24–48 h (mg/dL)1.50 ± 0.131.81 ± 0.180.93 ± 0.07< 0.001
 Serum creatinine 48–72 h (mg/dL)1.49 ± 0.111.79 ± 0.161.02 ± 0.12< 0.001
 Serum creatinine 7-day (mg/dL)1.87 ± 0.201.96 ± 0.210.89 ± 0.13< 0.001
 Serum creatinine 1-month (mg/dL)1.60 ± 0.131.68 ± 0.151.28 ± 0.25NS(0.208)
 Serum creatinine 3-month (mg/dL)1.59 ± 0.141.64 ± 0.161.31 ± 0.31NS(0.397)
 Hemoglobin (g/dL)12.9 ± 0.1512.0 ± 0.213.7 ± 0.2< 0.001
 Leukocytes (×103/μL)9.5 ± 0.310.0 ± 0.69.1 ± 0.3NS(0.174)
 Serum sodium (mmol/L)139 ± 0139 ± 0139 ± 0NS(0.379)
 hsCRP (mg/L)31 ± 342 ± 620 ± 30.001
 Troponin I (ng/ml)6.6 ± 1.05.4 ± 1.27.7 ± 1.7NS(0.272)
 BNP (pg/ml)725 ± 701025 ± 106382 ± 71< 0.001
 Ejection fraction (%)54 ± 151 ± 257 ± 10.004
 Albumin (g/L)3.7 ± 0.03.5 ± 0.13.9 ± 0.0< 0.001
  1. AKI Acute kidney injury, IL-18 Interleukin 18, NGAL Neutrophil gelatinase-associated lipocalin, CysC Cystatin C, hsCRP High sensitivity C-reactive protein, BNP B-type natriuretic peptide, NS Not significant