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Table 1 evolution of the symptoms, the treatment and IGRA results

From: Early diagnosis of miliary tuberculosis in a hemodialysis patient by combining two interferon-γ-release assays: a case report

Dates

October 2012

April 2013

July 2015

January 2016

February 2018

May 2018

Symptoms

Fever, myalgia

Fever, myalgia

Fever, myalgia

Absent

Absent

absent

PET-CT

Mediastinal adenopathies

Mediastinal adenopathies+ pulmonary nodules

Cervical, retro-clavicular, mediastinal, retroperitoneal, hepatic hilar adenopathies + pulmonary nodule

NA

NA

NA

M. tuberculosis culture/PCR

Negative

Negative

Positive

NA

NA

NA

Treatment

 Anti-TB

No

No

Yes

Yes

No

No

 Kidney graft

No

No

No

No

Yes

Yes

 Immuno-suppression

No

No

No

No

Yes

Yes

IGRA results (pg/ml)

 Neg control

0

NA

NA

0

NA

0

 Pos control

27,464

  

34,803

 

4767

 PPD

28,164

  

23,611

 

202

 HBHA

2862

  

6362

 

0

 ESAT-6

13,166

  

6118

 

85

  1. PET-CT: Positron Emission Tomography/Computed Tomography; Neg.: negative; Pos.: positive; NA: not available; IGRA: interferon--release assay; SEB: staphylococcal enterotoxin B; PPD: purified protein derivative; HBHA: heparin-binding-hemagglutinin; ESAT-6: early-secreted-antigen target-6; IGRA positivity limits: Pos control > 2000 pg/ml - PPD > 200 pg/ml - HBHA > 50 pg/ml – ESAT-6 > 50 pg/ml