Skip to main content

Table 2 Baseline pathological characteristics in IMN patients with and without DM

From: The impact of coexisting diabetes mellitus on clinical outcomes in patients with idiopathic membranous nephropathy: a retrospective observational study

Pathological characteristics

Non-DM

(n = 164)

DM

(n = 42)

P-value

Ehrenreich-Churg stage

  

0.578

MN I + II (n, %)

124 (75.6)

30 (71.4)

 

MN III + IV (n, %)

40 (24.4)

12 (28.6)

 

Glomerular sclerosis (n, %)

Global sclerosis

39 (23.8)

9 (21.4)

0.748

Segmental sclerosis

35 (21.3)

8 (19.4)

0.744

Tubular atrophy (n, %)

  

0.889

Atrophy area < 25%

157 (95.7)

40 (95.2)

 

Atrophy area ≥ 25%

7 (4.3)

2 (4.8)

 

Interstitial ICI (n, %)

143 (87.2)

38 (90.5)

0.561

Interstitial fibrosis (n, %)

54 (32.9)

14 (33.3)

0.960

Renal arteriopathy (n, %)

131 (79.9)

33 (78.6)

0.851

IgG subgroup deposit (n, %)

IgG1 (n, %)

133 (81.1)

35 (83.3)

0.739

IgG2 (n, %)

103 (62.8)

26 (61.9)

0.914

IgG3 (n, %)

73 (44.5)

18 (42.9)

0.847

IgG4 (n, %)

155 (94.5)

39 (92.9)

0.683

IgA deposit (n, %)

4 (2.4)

2 (4.8)

0.424

IgM deposit (n, %)

137 (83.5)

34 (81.0)

0.691

C3 deposit (n, %)

158 (96.3)

42 (100)

0.350

C1q deposit (n, %)

5 (3.0)

3 (7.1)

0.220

Positive PLA2R deposit (n, %)

127 (77.4)

35 (83.3)

0.406

Positive THSD7A deposit (n, %)a

0 (0)

0 (0)

–

Average GBMT (nm)

1440 ± 338

1524 ± 316

0.150

  1. Data were expressed as mean ± SD (standard deviation) or numbers (%)
  2. DM diabetes mellitus, MN membranous nephropathy, ICI inflammatory cell infiltration, PLA2R Phospholipase A2 Receptor, THSD7A Thrombospondin Type-1 Domain containing 7A, GBMT glomerular basement membrane thickness
  3. aThe detection of glomerular THSD7A antigen staining were available for 47 consecutive IMN patients between June 2017 to November 2017 due to the retrospective nature of the study