Vitamin D receptor gene polymorphisms and susceptibility to urolithiasis: a meta-regression and meta-analysis

Imani, Danyal; Razi, Bahman; Khosrojerdi, Arezou; Lorian, Kaivan; Motallebnezhad, Morteza; Rezaei, Ramazan; Aslani, Saeed

doi:10.1186/s12882-020-01919-1

BMC Nephrology

Table 1 Characteristics of studies included in meta-analysis of overall Urolithiasis

From: Vitamin D receptor gene polymorphisms and susceptibility to urolithiasis: a meta-regression and meta-analysis

Study author	Year	Country	Ethnicity	Sex cases/controls	Total cases/controls	Age case/control (Mean)	Genotyping method	Quality score
FokI (rs2228570)
Chen et al. (b)	2001	China	Asian	M = 101/42 F = 45/48	146 / 90	44.2 / 55.5	PCR–RFLP	6
Shaogang et al.	2003	China	Asian	M = 89/ 58 F = 61/22	150 / 80	43.6 ± 16/ 49 ± 19.6	PCR–RFLP	6
Rendina et al.	2004	Italy	European	M = 94/72 F = 65/52	159 / 124	43 ± 10.8 / 41.9 ± 10.4	PCR–RFLP	7
Mossetti et al.	2004	Italy	European	M = 66/ 73 F = 44/54	110 / 127	41.3 ± 13.5 / 41.06 ± 13.9	PCR–RFLP	6
Relan et al.	2004	India	Asian	M = 105/76 F = 45/24	150 / 100	39.3 ± 1.1 / 43.2 ± 2.05	PCR–RFLP	7
Bid et al. (a)	2005	India	Asian	M = NR F=NR	113 / 132	21–72 / 22–58	PCR–RFLP	6
Bid et al. (b)	2005	India	Asian	M = NR F=NR	50 / 60	2–14 / 4–16	PCR–RFLP	5
Liu et al.	2007	China	Asian	M = 161/159 F = 74/72	235 / 231	50.1 ± 12.3 / 51.7 ± 11.1	PCR–RFLP	8
Seo et al.	2009	Korea	Asian	M = 93/ 220 F = 185/313	278 / 533	49.9 / 40.1	PCR–RFLP	8
Mittal et al.	2010	India	Asian	M = NR F=NR	125 / 150	40 ± 11.5 / 41.5 ± 10.5	PCR–RFLP	7
Basiri et al.	2012	Iran	Asian	M = NR F=NR	102 / 106	43.4 ± 6.9 / 38.4 ± 6.9	SSP-PCR	6
Kaysar et al.	2012	China	Asian	M = NR F=NR	74 / 103	NR	PCR–RFLP	5
Wang et al.	2012	China	Asian	M = 279/263 F = 185/187	464 / 450	50.01 ± 10.19 / 50.45 ± 11.22	PCR–RFLP	8
Guha et al.	2015	India	Asian	M = 133 / 112 F = 67 / 78	200 /200	39.93 ± 11 / 38.13 ± 10	PCR	7
Cakir et al.	2016	Turkey	European	M = 65 / 52 F = 33 / 18	98 / 70	47.2 ± 16.3 / 42.6 ± 13.5	PCR–RFLP	6
Ergon et al.	2017	Turkey	European	M = NR F=NR	27 / 13	7.12 ± 2.64 / 6.92 ± 2.48	Tag-man	5
Subasi et al.	2017	Turkey	European	M = 26/22 F = 26/29	52 / 51	9.8 ± 3.5 / 10.3 ± 3.7	SNaPshot	5
Li et al.	2018	China	Asian	M = 100/60 F = 100/60	200 / 120	35.88 ± 14.2 / 36.16 ± 15.20	PCR	7
Huang et al.	2019	China	Asian	M = NR F=NR	130 / 224	4.55 ± 3.19 / 5.02 ± 3.50	PCR–RFLP	7
Amar et al.	2019	Pakistani	Asian	M = NR F=NR	235 / 243	NR	PCR–RFLP	7
TaqI (rs731236)
Jackman et al.	1999	USA	American	M = NR F=NR	17 / 37	NR	PCR–RFLP	5
Nishijima et al.	2002	Japan	Asian	M = NR F=NR	83 / 83	51.8 ± 15.6 / 54.4 ± 13.1	PCR–RFLP	5
Ozkaya et al.	2003	Turkey	European	M = 26/ 47 F = 38/43	64 / 90	6.7 ± 3.5 / 7.2 ± 2.3	PCR–RFLP	5
Mossetti et al.	2003	Italy	European	M = NR F=NR	220/114	40.87 ± 14.95 / 40.37 ± 14.07	PCR–RFLP	7
Shaogang et al.	2003	China	Asian	M = 89/ 58 F = 61/22	150 / 80	43.6 ± 16 / 49 ± 19.6	PCR–RFLP	6
Mossetti et al.	2004	Italy	European	M = 66/ 73 F = 44/54	110 / 127	41.3 ± 13.5 / 41.06 ± 13.9	PCR–RFLP	6
Gunes et al.	2006	Turkey	European	M = 67/ 73 F = 43/77	110 / 150	49.22 ± 1.33 / 48.15 ± 1.62	PCR–RFLP	7
Sayan et al.	2007	Turkey	European	M = 65/ 25 F = 15/15	80 / 40	10.9 ± 0.6 / 10.5 ± 0.6	PCR–RFLP	5
Moyano et al.	2007	Spain	European	M = 22/ 9 F = 29/12	51 / 21	45.5 ± 13.5 / 48.6 ± 15.4	PCR–RFLP	5
Seo et al.	2009	Korea	Asian	M = 93/ 220 F = 185/313	278 / 533	49.9 / 40.1	PCR–RFLP	8
Mittal et al.	2010	India	Asian	M = NR F=NR	125 / 150	40 ± 11.5 / 41.5 ± 10.5	PCR–RFLP	7
Basiri et al.	2012	Iran	Asian	M = NR F=NR	102 / 106	43.4 ± 6.9 / 38.4 ± 6.9	SSP-PCR	6
Wang et al.	2012	China	Asian	M = 279/263 F = 185/187	464 / 450	50.01 ± 10.19 / 50.45 ± 11.22	PCR–RFLP	8
Aykan et al.	2015	Turkey	European	M = 100/87 F = 64/ 80	164 / 167	24–58 / 38–54	PCR–RFLP	7
Guha et al.	2015	India	Asian	M = 133 / 112 F = 67 / 78	200 / 200	39.93 ± 11 / 38.13 ± 10	PCR	7
Rendina et al.	2016	Italy	European	M = NR F=NR	372 / 88	41.2 ± 13.3 / 40.8 ± 14.1	PCR–RFLP	7
Cakir et al.	2016	Turkey	European	M = 65 / 52 F = 33 / 18	98 / 70	47.2 ± 16.3 / 42.6 ± 13.5	PCR–RFLP	6
Goknar et al.	2016	Turkey	European	M = NR F=NR	78 / 60	6.94 ± 3.8 / 7.5 ± 3.2	PCR–RFLP	6
Subasi et al.	2017	Turkey	European	M = 26/22 F = 26/29	52 / 51	9.8 ± 3.5 / 10.3 ± 3.7	SNaPshot	5
Li et al.	2018	China	Asian	M = 100/60 F = 100/60	200 / 120	35.88 ± 14.2 / 36.16 ± 15.20	PCR	7
Yang et al.	2019	China	Asian	M = 627/614 F = 316/361	943 / 975	51.2 ± 14.13 / 54.33 ± 18.11	iMLDR	8
Amar et al.	2019	Pakistani	Asian	M = NR F=NR	227 / 243	NR	PCR–RFLP	7
BsmI (rs1544410)
Ruggiero et al.	1999	Italy	European	M = 18/NR F = 9/ NR	27 / 150	NR	PCR–RFLP	6
Chen et al. (a)	2001	China	Asian	M = 94/55 F = 30/ 35	124 / 90	44.1 ± 11.5 / 53 ± 10.1	PCR–RFLP	6
Ozkaya et al.	2003	turkey	European	M = 26/ 47 F = 38/43	64 / 90	6.7 ± 3.5 / 7.2 ± 2.3	PCR–RFLP	5
Rendina et al.	2004	Italy	European	M = 94/72 F = 65/52	159 / 124	43 ± 10.8 / 41.9 ± 10.4	PCR–RFLP	7
Mossetti et al.	2004	Italy	European	M = 66/ 73 F = 44/54	110 / 127	41.3 ± 13.5 / 41.06 ± 13.9	PCR–RFLP	6
Relan et al.	2004	India	Asia	M = 105/76 F = 45/24	150 / 100	39.3 ± 1.1 / 43.2 ± 2.05	PCR–RFLP	7
Gunes et al.	2006	turkey	European	M = 67/ 73 F = 43/77	110 / 150	49.22 ± 1.33 / 48.15 ± 1.62	PCR–RFLP	7
Moyano et al.	2007	Spain	European	M = 22/ 9 F = 29/12	51 / 21	45.5 ± 13.5 / 48.6 ± 15.4	PCR–RFLP	5
Wang et al.	2012	China	Asian	M = 279/263 F = 185/187	464 / 450	50.01 ± 10.19 / 50.45 ± 11.22	PCR–RFLP	8
Cakir et al.	2016	Turkey	European	M = 65 / 52 F = 33 / 18	98/ 70	47.2 ± 16.3 / 42.6 ± 13.5	PCR–RFLP	6
Goknar et al.	2016	Turkey	European	M = NR F=NR	72/ 53	6.94 ± 3.8 / 7.5 ± 3.2	PCR–RFLP	6
Subasi et al.	2017	turkey	European	M = 26/22 F = 26/29	52 / 51	9.8 ± 3.5 / 10.3 ± 3.7	SNaPshot	5
Li et al.	2018	China	Asian	M = 100/60 F = 100/60	200 / 120	35.88 ± 14.2 / 36.16 ± 15.20	PCR	7
Yang et al.	2019	China	Asian	M = 627/614 F = 316/361	943 / 975	51.2 ± 14.13 / 54.33 ± 18.11	iMLDR	8
ApaI (rs7975232)
Nishijima et al.	2002	Japan	Asian	M = NR F=NR	83 / 83	51.8 ± 15.6 / 54.4 ± 13.1	PCR–RFLP	5
Shaogang et al.	2003	China	Asian	M = 89/ 58 F = 61/22	150 / 80	43.6 ± 16 / 49 ± 19.6	PCR–RFLP	6
Ozkaya et al.	2003	Turkey	Asian	M = 26/ 47 F = 38/43	64 / 90	6.7 ± 3.5 / 7.2 ± 2.3	PCR–RFLP	5
Rendina et al.	2004	Italy	European	M = 94/72 F = 65/52	159 / 124	43 ± 10.8 / 41.9 ± 10.4	PCR–RFLP	7
Gunes et al.	2006	Turkey	European	M = 67/ 73 F = 43/77	110 / 150	49.22 ± 1.33 / 48.15 ± 1.62	PCR–RFLP	7
Moyano et al.	2007	Spain	European	M = 22/ 9 F = 29/12	51 / 21	45.5 ± 13.5 / 48.6 ± 15.4	PCR–RFLP	5
Seo et al.	2009	Korea	Asian	M = 88/ 220 F = 185/305	273 / 525	49.9 / 40.1	PCR–RFLP	8
Mittal et al.	2010	India	Asian	M = NR F=NR	125 / 150	40 ± 11.5 / 41.5 ± 10.5	PCR–RFLP	7
Kaysar et al.	2012	China	Asian	M = NR F=NR	74 / 103	NR	PCR–RFLP	5
Wang et al.	2012	China	Asian	M = NR F=NR	463 / 450	50.01 ± 10.19 / 50.45 ± 11.22	PCR–RFLP	8
Cakir et al.	2016	Turkey	European	M = 65 / 52 F = 33 / 18	98/ 70	47.2 ± 16.3 / 42.6 ± 13.5	PCR–RFLP	6
Goknar et al.	2016	Turkey	European	M = NR F=NR	78/ 60	6.94 ± 3.8 / 7.5 ± 3.2	PCR–RFLP	6
Ergon et al.	2017	Turkey	European	M = NR F=NR	27 / 13	7.12 ± 2.64 / 6.92 ± 2.48	Tag-man	5
Subasi et al.	2017	Turkey	European	M = 26/22 F = 26/29	52 / 51	9.8 ± 3.5 / 10.3 ± 3.7	SNaPshot	5
Li et al.	2018	China	Asian	M = 100/60 F = 100/60	200 / 120	35.88 ± 14.2 / 36.16 ± 15.20	PCR	7
Yang et al.	2019	China	Asian	M = 627/614 F = 316/361	943 / 975	51.2 ± 14.13 / 54.33 ± 18.11	iMLDR	8

Abbreviations: NR not reported, M male, F female

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