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Table 1 Characteristics of studies included in meta-analysis of overall Urolithiasis

From: Vitamin D receptor gene polymorphisms and susceptibility to urolithiasis: a meta-regression and meta-analysis

Study author Year Country Ethnicity Sex
cases/controls
Total cases/controls Age
case/control (Mean)
Genotyping method Quality
score
FokI (rs2228570)
 Chen et al. (b) 2001 China Asian M = 101/42
F = 45/48
146 / 90 44.2 / 55.5 PCR–RFLP 6
 Shaogang et al. 2003 China Asian M = 89/ 58
F = 61/22
150 / 80 43.6 ± 16/ 49 ± 19.6 PCR–RFLP 6
 Rendina et al. 2004 Italy European M = 94/72
F = 65/52
159 / 124 43 ± 10.8 / 41.9 ± 10.4 PCR–RFLP 7
 Mossetti et al. 2004 Italy European M = 66/ 73
F = 44/54
110 / 127 41.3 ± 13.5 / 41.06 ± 13.9 PCR–RFLP 6
 Relan et al. 2004 India Asian M = 105/76
F = 45/24
150 / 100 39.3 ± 1.1 / 43.2 ± 2.05 PCR–RFLP 7
 Bid et al. (a) 2005 India Asian M = NR
F=NR
113 / 132 21–72 / 22–58 PCR–RFLP 6
 Bid et al. (b) 2005 India Asian M = NR
F=NR
50 / 60 2–14 / 4–16 PCR–RFLP 5
 Liu et al. 2007 China Asian M = 161/159
F = 74/72
235 / 231 50.1 ± 12.3 / 51.7 ± 11.1 PCR–RFLP 8
 Seo et al. 2009 Korea Asian M = 93/ 220
F = 185/313
278 / 533 49.9 / 40.1 PCR–RFLP 8
 Mittal et al. 2010 India Asian M = NR
F=NR
125 / 150 40 ± 11.5 / 41.5 ± 10.5 PCR–RFLP 7
 Basiri et al. 2012 Iran Asian M = NR
F=NR
102 / 106 43.4 ± 6.9 / 38.4 ± 6.9 SSP-PCR 6
 Kaysar et al. 2012 China Asian M = NR
F=NR
74 / 103 NR PCR–RFLP 5
 Wang et al. 2012 China Asian M = 279/263
F = 185/187
464 / 450 50.01 ± 10.19 / 50.45 ± 11.22 PCR–RFLP 8
 Guha et al. 2015 India Asian M = 133 / 112
F = 67 / 78
200 /200 39.93 ± 11 / 38.13 ± 10 PCR 7
 Cakir et al. 2016 Turkey European M = 65 / 52
F = 33 / 18
98 / 70 47.2 ± 16.3 / 42.6 ± 13.5 PCR–RFLP 6
 Ergon et al. 2017 Turkey European M = NR
F=NR
27 / 13 7.12 ± 2.64 / 6.92 ± 2.48 Tag-man 5
 Subasi et al. 2017 Turkey European M = 26/22
F = 26/29
52 / 51 9.8 ± 3.5 / 10.3 ± 3.7 SNaPshot 5
 Li et al. 2018 China Asian M = 100/60
F = 100/60
200 / 120 35.88 ± 14.2 / 36.16 ± 15.20 PCR 7
 Huang et al. 2019 China Asian M = NR
F=NR
130 / 224 4.55 ± 3.19 / 5.02 ± 3.50 PCR–RFLP 7
 Amar et al. 2019 Pakistani Asian M = NR
F=NR
235 / 243 NR PCR–RFLP 7
TaqI (rs731236)
 Jackman et al. 1999 USA American M = NR
F=NR
17 / 37 NR PCR–RFLP 5
 Nishijima et al. 2002 Japan Asian M = NR
F=NR
83 / 83 51.8 ± 15.6 / 54.4 ± 13.1 PCR–RFLP 5
 Ozkaya et al. 2003 Turkey European M = 26/ 47
F = 38/43
64 / 90 6.7 ± 3.5 / 7.2 ± 2.3 PCR–RFLP 5
 Mossetti et al. 2003 Italy European M = NR
F=NR
220/114 40.87 ± 14.95 / 40.37 ± 14.07 PCR–RFLP 7
 Shaogang et al. 2003 China Asian M = 89/ 58
F = 61/22
150 / 80 43.6 ± 16 / 49 ± 19.6 PCR–RFLP 6
 Mossetti et al. 2004 Italy European M = 66/ 73
F = 44/54
110 / 127 41.3 ± 13.5 / 41.06 ± 13.9 PCR–RFLP 6
 Gunes et al. 2006 Turkey European M = 67/ 73
F = 43/77
110 / 150 49.22 ± 1.33 / 48.15 ± 1.62 PCR–RFLP 7
 Sayan et al. 2007 Turkey European M = 65/ 25
F = 15/15
80 / 40 10.9 ± 0.6 / 10.5 ± 0.6 PCR–RFLP 5
 Moyano et al. 2007 Spain European M = 22/ 9
F = 29/12
51 / 21 45.5 ± 13.5 / 48.6 ± 15.4 PCR–RFLP 5
 Seo et al. 2009 Korea Asian M = 93/ 220
F = 185/313
278 / 533 49.9 / 40.1 PCR–RFLP 8
 Mittal et al. 2010 India Asian M = NR
F=NR
125 / 150 40 ± 11.5 / 41.5 ± 10.5 PCR–RFLP 7
 Basiri et al. 2012 Iran Asian M = NR
F=NR
102 / 106 43.4 ± 6.9 / 38.4 ± 6.9 SSP-PCR 6
 Wang et al. 2012 China Asian M = 279/263
F = 185/187
464 / 450 50.01 ± 10.19 / 50.45 ± 11.22 PCR–RFLP 8
 Aykan et al. 2015 Turkey European M = 100/87
F = 64/ 80
164 / 167 24–58 / 38–54 PCR–RFLP 7
 Guha et al. 2015 India Asian M = 133 / 112
F = 67 / 78
200 / 200 39.93 ± 11 / 38.13 ± 10 PCR 7
 Rendina et al. 2016 Italy European M = NR
F=NR
372 / 88 41.2 ± 13.3 / 40.8 ± 14.1 PCR–RFLP 7
 Cakir et al. 2016 Turkey European M = 65 / 52
F = 33 / 18
98 / 70 47.2 ± 16.3 / 42.6 ± 13.5 PCR–RFLP 6
 Goknar et al. 2016 Turkey European M = NR
F=NR
78 / 60 6.94 ± 3.8 / 7.5 ± 3.2 PCR–RFLP 6
 Subasi et al. 2017 Turkey European M = 26/22
F = 26/29
52 / 51 9.8 ± 3.5 / 10.3 ± 3.7 SNaPshot 5
 Li et al. 2018 China Asian M = 100/60
F = 100/60
200 / 120 35.88 ± 14.2 / 36.16 ± 15.20 PCR 7
 Yang et al. 2019 China Asian M = 627/614
F = 316/361
943 / 975 51.2 ± 14.13 / 54.33 ± 18.11 iMLDR 8
 Amar et al. 2019 Pakistani Asian M = NR
F=NR
227 / 243 NR PCR–RFLP 7
BsmI (rs1544410)
 Ruggiero et al. 1999 Italy European M = 18/NR
F = 9/ NR
27 / 150 NR PCR–RFLP 6
 Chen et al. (a) 2001 China Asian M = 94/55
F = 30/ 35
124 / 90 44.1 ± 11.5 / 53 ± 10.1 PCR–RFLP 6
 Ozkaya et al. 2003 turkey European M = 26/ 47
F = 38/43
64 / 90 6.7 ± 3.5 / 7.2 ± 2.3 PCR–RFLP 5
 Rendina et al. 2004 Italy European M = 94/72
F = 65/52
159 / 124 43 ± 10.8 / 41.9 ± 10.4 PCR–RFLP 7
 Mossetti et al. 2004 Italy European M = 66/ 73
F = 44/54
110 / 127 41.3 ± 13.5 / 41.06 ± 13.9 PCR–RFLP 6
 Relan et al. 2004 India Asia M = 105/76
F = 45/24
150 / 100 39.3 ± 1.1 / 43.2 ± 2.05 PCR–RFLP 7
 Gunes et al. 2006 turkey European M = 67/ 73
F = 43/77
110 / 150 49.22 ± 1.33 / 48.15 ± 1.62 PCR–RFLP 7
 Moyano et al. 2007 Spain European M = 22/ 9
F = 29/12
51 / 21 45.5 ± 13.5 / 48.6 ± 15.4 PCR–RFLP 5
 Wang et al. 2012 China Asian M = 279/263
F = 185/187
464 / 450 50.01 ± 10.19 / 50.45 ± 11.22 PCR–RFLP 8
 Cakir et al. 2016 Turkey European M = 65 / 52
F = 33 / 18
98/ 70 47.2 ± 16.3 / 42.6 ± 13.5 PCR–RFLP 6
 Goknar et al. 2016 Turkey European M = NR
F=NR
72/ 53 6.94 ± 3.8 / 7.5 ± 3.2 PCR–RFLP 6
 Subasi et al. 2017 turkey European M = 26/22
F = 26/29
52 / 51 9.8 ± 3.5 / 10.3 ± 3.7 SNaPshot 5
 Li et al. 2018 China Asian M = 100/60
F = 100/60
200 / 120 35.88 ± 14.2 / 36.16 ± 15.20 PCR 7
 Yang et al. 2019 China Asian M = 627/614
F = 316/361
943 / 975 51.2 ± 14.13 / 54.33 ± 18.11 iMLDR 8
ApaI (rs7975232)
 Nishijima et al. 2002 Japan Asian M = NR
F=NR
83 / 83 51.8 ± 15.6 / 54.4 ± 13.1 PCR–RFLP 5
 Shaogang et al. 2003 China Asian M = 89/ 58
F = 61/22
150 / 80 43.6 ± 16 / 49 ± 19.6 PCR–RFLP 6
 Ozkaya et al. 2003 Turkey Asian M = 26/ 47
F = 38/43
64 / 90 6.7 ± 3.5 / 7.2 ± 2.3 PCR–RFLP 5
 Rendina et al. 2004 Italy European M = 94/72
F = 65/52
159 / 124 43 ± 10.8 / 41.9 ± 10.4 PCR–RFLP 7
 Gunes et al. 2006 Turkey European M = 67/ 73
F = 43/77
110 / 150 49.22 ± 1.33 / 48.15 ± 1.62 PCR–RFLP 7
 Moyano et al. 2007 Spain European M = 22/ 9
F = 29/12
51 / 21 45.5 ± 13.5 / 48.6 ± 15.4 PCR–RFLP 5
 Seo et al. 2009 Korea Asian M = 88/ 220
F = 185/305
273 / 525 49.9 / 40.1 PCR–RFLP 8
 Mittal et al. 2010 India Asian M = NR
F=NR
125 / 150 40 ± 11.5 / 41.5 ± 10.5 PCR–RFLP 7
 Kaysar et al. 2012 China Asian M = NR
F=NR
74 / 103 NR PCR–RFLP 5
 Wang et al. 2012 China Asian M = NR
F=NR
463 / 450 50.01 ± 10.19 / 50.45 ± 11.22 PCR–RFLP 8
 Cakir et al. 2016 Turkey European M = 65 / 52
F = 33 / 18
98/ 70 47.2 ± 16.3 / 42.6 ± 13.5 PCR–RFLP 6
 Goknar et al. 2016 Turkey European M = NR
F=NR
78/ 60 6.94 ± 3.8 / 7.5 ± 3.2 PCR–RFLP 6
 Ergon et al. 2017 Turkey European M = NR
F=NR
27 / 13 7.12 ± 2.64 / 6.92 ± 2.48 Tag-man 5
 Subasi et al. 2017 Turkey European M = 26/22
F = 26/29
52 / 51 9.8 ± 3.5 / 10.3 ± 3.7 SNaPshot 5
 Li et al. 2018 China Asian M = 100/60
F = 100/60
200 / 120 35.88 ± 14.2 / 36.16 ± 15.20 PCR 7
 Yang et al. 2019 China Asian M = 627/614
F = 316/361
943 / 975 51.2 ± 14.13 / 54.33 ± 18.11 iMLDR 8
  1. Abbreviations: NR not reported, M male, F female