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Table 3 Univariate Cox hazard model for all-cause mortality in hemodialysis patients

From: Premature aging of circulating T cells predicts all-cause mortality in hemodialysis patients

Variables Hazard Ratio (95% Confidence Interval) P value
Age (years) 1.070 (1.053, 1.088) < 0.001
Sex (male = 1) 1.121 (0.751, 1.672) 0.577
Diabetes mellitus (yes = 1) 1.911 (1.271, 2.874) 0.002
CVD (yes = 1) 3.977 (2.679, 5.906) < 0.001
BMI (kg/m2) 0.959 (0.907, 1.015) 0.149
Kt/Vurea 0.893 (0.586, 1.360) 0.598
Time on HD (month) 0.996 (0.992, 1.001) 0.086
Hemoglobin (g/L) 0.991 (0.979, 1.002) 0.119
Albumin (g/L) 0.816 (0.773, 0.862) < 0.001
Prealbumin (g/L) 0.021 (0.003, 0.154) < 0.001
Urea nitrogen (mmol/L) 0.965 (0.935, 0.995) 0.024
Creatinine (μmol/L) 0.998 (0.997, 0.999) < 0.001
Uric acid (mmol/L) 0.995 (0.993, 0.998) < 0.001
Phosphorus (mmol/L) 0.826 (0.606, 1.125) 0.225
Calcium (mmol/L) 0.602 (0.279, 1.296) 0.195
Log-iPTH (pg/ml) 0.973 (0.584, 1.619) 0.915
β2-Microglobulin (mg/L) 1.020 (0.995, 1.045) 0.117
Homocysteine (μmol/L) 0.993 (0.985, 1.001) 0.067
Log-hsCRP (mg/L) 1.930 (1.376, 2.705) < 0.001
Log-sIL-2R (U/ml) 16.328 (4.157, 64.140) < 0.001
Log-NT-proBNP (pg/mL) 4.089 (2.690, 6.216) < 0.001
T cell count (cells/μl) 0.223 (0.113, 0.440) < 0.001
Naïve t cell count (cells/μl) 0.002 (0.000, 0.018) < 0.001
CD4+naïve T cell count (cells/μl) 0.001 (0.000, 0.012) < 0.001
CD8+naïve T cell count (cells/μl) 0.000 (0.000, 0.000) < 0.001
T cell (%) 0.059 (0.015, 0.241) < 0.001
Naïve T cell (%) 0.032 (0.006, 0.159) < 0.001
CD4+naïve T cell (%) 0.086 (0.023, 0.327) < 0.001
CD4+effector-memory T cell (%) 8.563 (2.139, 34.271) 0.002
CD8+naïve T cell (%) 0.006 (0.001, 0.042) < 0.001
CD8+central memory T cell (%) 2.313 (1.211, 4.421) 0.011
CD8+effector memory T cell (%) 7.253(1.684, 31.242) 0.008
CD8+EMRA T cell (%) 4.290 (1.367, 13.461) 0.013
  1. CVD cardiovascular disease; BMI Body mass index; HD hemodialysis; Log-hsCRP log transformed high sensitivity-C reactive protein; Log-sIL-2R log transformed soluble interleukin-2 receptor; Log-NT-proBNP log transformed N-terminal pro-brain natriuretic peptide