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Table 3 Univariate Cox hazard model for all-cause mortality in hemodialysis patients

From: Premature aging of circulating T cells predicts all-cause mortality in hemodialysis patients

Variables

Hazard Ratio (95% Confidence Interval)

P value

Age (years)

1.070 (1.053, 1.088)

< 0.001

Sex (male = 1)

1.121 (0.751, 1.672)

0.577

Diabetes mellitus (yes = 1)

1.911 (1.271, 2.874)

0.002

CVD (yes = 1)

3.977 (2.679, 5.906)

< 0.001

BMI (kg/m2)

0.959 (0.907, 1.015)

0.149

Kt/Vurea

0.893 (0.586, 1.360)

0.598

Time on HD (month)

0.996 (0.992, 1.001)

0.086

Hemoglobin (g/L)

0.991 (0.979, 1.002)

0.119

Albumin (g/L)

0.816 (0.773, 0.862)

< 0.001

Prealbumin (g/L)

0.021 (0.003, 0.154)

< 0.001

Urea nitrogen (mmol/L)

0.965 (0.935, 0.995)

0.024

Creatinine (μmol/L)

0.998 (0.997, 0.999)

< 0.001

Uric acid (mmol/L)

0.995 (0.993, 0.998)

< 0.001

Phosphorus (mmol/L)

0.826 (0.606, 1.125)

0.225

Calcium (mmol/L)

0.602 (0.279, 1.296)

0.195

Log-iPTH (pg/ml)

0.973 (0.584, 1.619)

0.915

β2-Microglobulin (mg/L)

1.020 (0.995, 1.045)

0.117

Homocysteine (μmol/L)

0.993 (0.985, 1.001)

0.067

Log-hsCRP (mg/L)

1.930 (1.376, 2.705)

< 0.001

Log-sIL-2R (U/ml)

16.328 (4.157, 64.140)

< 0.001

Log-NT-proBNP (pg/mL)

4.089 (2.690, 6.216)

< 0.001

T cell count (cells/μl)

0.223 (0.113, 0.440)

< 0.001

Naïve t cell count (cells/μl)

0.002 (0.000, 0.018)

< 0.001

CD4+naïve T cell count (cells/μl)

0.001 (0.000, 0.012)

< 0.001

CD8+naïve T cell count (cells/μl)

0.000 (0.000, 0.000)

< 0.001

T cell (%)

0.059 (0.015, 0.241)

< 0.001

Naïve T cell (%)

0.032 (0.006, 0.159)

< 0.001

CD4+naïve T cell (%)

0.086 (0.023, 0.327)

< 0.001

CD4+effector-memory T cell (%)

8.563 (2.139, 34.271)

0.002

CD8+naïve T cell (%)

0.006 (0.001, 0.042)

< 0.001

CD8+central memory T cell (%)

2.313 (1.211, 4.421)

0.011

CD8+effector memory T cell (%)

7.253(1.684, 31.242)

0.008

CD8+EMRA T cell (%)

4.290 (1.367, 13.461)

0.013

  1. CVD cardiovascular disease; BMI Body mass index; HD hemodialysis; Log-hsCRP log transformed high sensitivity-C reactive protein; Log-sIL-2R log transformed soluble interleukin-2 receptor; Log-NT-proBNP log transformed N-terminal pro-brain natriuretic peptide
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BMC Nephrology

ISSN: 1471-2369

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