Fig. 4

Examples of discordance between histology and eGFR slopes. Several patients in our cohort had eGFR trajectories that were highly discordant with the severity of histologic findings, highlighting the lack of correlation between eGFR slope and histology. Panel a contrasts the eGFR slope of a slow progressor with advanced interstitial fibrosis, while panel b demonstrates rapid eGFR decline despite mild interstitial fibrosis. eGFR, estimated glomerular filtration rate; RPS, Renal Pathology Society. Scale bar, 200 μm. [IN COLOUR]