Table 1 Baseline clinical and histologic information for entire cohort, stratified by progressor class
Progressor class | All | Slow progressors | Moderate progressors | Fast progressors | P value |
|---|---|---|---|---|---|
No. of patients (%) | 50 (100) | 20 (40) | 16 (32) | 14 (28) | |
eGFR slope, ml/min/yr (med, IQR) | −5.8 (−12.4, −3.1) | −2.3 (− 3.6,1.0) | −6.5 (−7.8–5.7) | −17.4 (− 28.2, − 13.9) | < 0.001 |
FU data points (med, IQR) | 13 (8, − 17.75) | 13 (12,18) | 14 (11,21) | 9.5 (7.2,14.2) | 0.2 |
FU time,years (med, IQR) | 2.53 (1.22,3.65) | 2.81 (2.39,4.49) | 2.8 (2.03,4.35) | 1.13 (0.88, 2.43) | 0.01 |
Sex male (n,%) | 32 (64) | 14 (70) | 10 (62.5) | 8 (57.1) | 0.7 |
Age,years (med, IQR) | 56 (47.25–62.75) | 58 (54.8,64.2) | 52.5 (46.8 59.2) | 50 (46.2,58.5) | 0.2 |
eGFR,mls/min (med, IQR) | 43.1 (28.7,52.6) | 37.2 (19.7,51.2) | 38.7 (28.1–67.7) | 45.3 (41.4, 52) | 0.3 |
ACR, mg/mmol (med, IQR) | 216 (114,477) | 173 (70.6212.5) | 260 (121,581) | 742 (284,999) | 0.004 |
HbA1c, % (med, IQR) | 7.4 (6.6–9.1) | 6.8 (6.4,7.5) | 7.6 (6.8,8.9) | 9.0 (6.8,11.8) | 0.05 |
Use of insulin (n, %) | 33 (66) | 11 (55) | 13 (81.2) | 9 (64.3) | 0.3 |
#OHG (mean) | 0.9 | 1.15 | 0.75 | 0.714 | 0.4 |
SBP, mmHg (med, IQR) | 156 (141–172) | 151 (141,172) | 154 (132–171) | 157 (146,165) | 0.9 |
#Anti-HTN (mean) | 3.32 | 3.1 | 3.44 | 3.5 | 0.8 |
Use of RASi (n,%) | 39 (78) | 16 (80) | 13 (81.2) | 10 (71.4) | 0.8 |
Use of statin (n,%) | 39 (78) | 15 (75) | 14 (87.5) | 10 (71.4) | 0.5 |
Hb (mg/L, IQR) | 110 (96.5122.2) | 109 (96.5–120) | 111 (99.75–127) | 110 (98.25–117.25) | 0.9 |
Renal death (n,%) | 20 (40) | 4 (20) | 7 (43.8) | 9 (64.3) | 0.03 |
Glomerular Class (%) | 0.9 | ||||
I | 2 (4.0) | 1 (5.3) | 1 (6.3) | 0 (0) | |
II | 7 (14.3) | 3 (15.8) | 2 (12.5) | 2 (14.2) | |
III | 33 (67.3) | 12 (63.2) | 11 (68.8) | 10 (71.4) | |
IV | 7 (14.3) | 3 (15.8) | 2 (12.5) | 2 (14.3) | |
IF/TA Score % | 0.9 | ||||
0 | 0 (0) | 0 (0) | 0 (0) | 0 (0) | |
1 | 16 (32) | 6 (30) | 5 (31.3) | 5 (35.7) | |
2 | 20 (40) | 8 (40) | 8 (50) | 4 (28.6) | |
3 | 14 (28) | 6 (30) | 3 (18.8) | 5 (35.7) | |
Arteriolar Hyalinosis Score % | 0.6 | ||||
0 | 4 (8) | 2 (10) | 2 (12.5) | 0 (0) | |
1 | 14 (28) | 5 (25) | 5 (31.3) | 4 (28.6) | |
2 | 32 (64) | 13 (65) | 9 (56.3) | 10 (71.4) | |
Arteriosclerosis Score % | 0.4 | ||||
0 | 2 (4.2) | 1 (5.3) | 0 (0) | 1 (7.1) | |
1 | 21 (44.7) | 10 (52.6) | 5 (35.7) | 6 (42.9) | |
2 | 24 (51.1) | 8 (42.1) | 9 (64.3) | 7 (50) |