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Table 2 Univariable and multivariable regression analysis of factors associated with trabecular bone score in hemodialysis patients

From: Trabecular bone score may indicate chronic kidney disease-mineral and bone disorder (CKD-MBD) phenotypes in hemodialysis patients: a prospective observational study

Variable (N = 57)

Univariable

Multivariable

ß

95% CI

p-value

ß

95% CI

p-value†

Age, per 10 years

−0.042

−0.055 – −0.028

< 0.001

− 0.030

− 0.049 – − 0.012

0.001

Female vs. Male

− 0.051

− 0.105 – 0.002

0.059

− 0.012

−0.084 – 0.061

0.747

Dialysis vintage (years)

−0.002

−0.008 – 0.003

0.426

0.001

−0.004 – 0.006

0.702

BMI, per 5 kg/m2

−0.024

−0.058 – 0.010

0.162

   

DM vs. Non-DM

−0.008

−0.064 – 0.048

0.768

0.034

−0.017 – 0.086

0.186

CVE vs. No-CVE

−0.010

−0.150 – − 0.050

< 0.001

−0.055

− 0.103 – − 0.008

0.024

Hemoglobin (g/dl)

0.016

−0.017 – 0.048

0.333

   

BUN, per 10 mg/dl

0.016

−0.001 – 0.034

0.071

   

Creatinine (mg/dl)

0.009

0.002–0.017

0.019

   

Albumin (g/dl)

0.043

−0.016 – 0.103

0.146

0.001

−0.051 – 0.054

0.957

LDL, per 50 mg/dl

0.024

−0.021 – 0.068

0.294

   

Calcium (mg/dl)

−0.031

−0.067 – 0.006

0.096

   

Phosphate (mg/dl)

0.017

−0.001 – 0.034

0.061

   

ALP, per 25 U/L

0.007

−0.003 – 0.016

0.152

   

iPTH, per 100 pg/ml

0.011

0.001–0.022

0.039

0.005

−0.005 – 0.015

0.321

ln α-klotho (pg/ml)

0.007

−0.047 – 0.062

0.793

   

ln FGF 23 (pg/ml)

0.008

−0.009 – 0.025

0.334

−0.004

−0.020 – 0.012

0.594

Tilburg frailty indicator

−0.003

−0.013 – 0.008

0.626

   

Handgrip strength, per 10 kg.f

0.039

0.019–0.059

< 0.001

0.020

−0.012 – 0.051

0.213

Phase angle (°)

0.030

0.011–0.048

0.002

   

PG-SGA

−0.006

− 0.011 – 0.001

0.029

   

Phosphate binder dosea

0.012

−0.003 – 0.029

0.114

−0.001

−0.016 – 0.015

0.919

L-spine BMD (g/cm2)

0.185

0.069–0.301

0.002

   
  1. Abbreviations: ß, Regression coefficient of univariable or multivariable linear regression, CI Confidence interval, BMI, Body mass index, DM Diabetes mellitus, CVE Cardiovascular events, BUN Blood urea nitrogen, LDL Low density lipoprotein, ALP Alkaline phosphatase, PTH Parathyroid hormone, FGF 23 Fibroblast growth factor 23, PG-SGA Patient-generated subjective global assessment, BMD Bone mineral density
  2. aPhosphate binder dose (per BSA/week), per 3500 mg
  3. †Adjusted p-value