Table 1 Chart enumerating details of 4 recent case reports of COVID-19 patients who had renal biopsies. M male, AA African-American, S. Cr serum creatinine, UPCr urine protein-creatinine ratio, DM diabetes mellitus, HTN hypertension, AKI acute kidney injury, CKD chronic kidney disease, UA urinalysis, ATI acute tubular injury, ATN acute tubular necrosis, LM light microscopy, IF immunofluorescence, Neg negative, CG collapsing glomerulopathy or collapsing-type focal segmental glomerulosclerosis, EM electron microscopy, ITEDD immune-type electron-dense deposits, APOL1 apolipoprotein 1
Published reports | Age/Sex/Ethnicity | Renal-associated signs & symptoms | Pre-existing disease(s) | Recent NSAID use | Renal biopsy findings | APOL1 gene testing |
|---|---|---|---|---|---|---|
Larsen et al. [5] (1 case) | 44/M/AA | AKI with S. Cr of 4.0 mg/dl, UA positive for blood and protein, spot UPCr 3.9 g/g | Poorly-controlled type 2 DM, HTN, dyslipidemia, CKD | Not known | LM: CG, ATI/ATN IF: Neg EM: severe FPE, no ITEDD present, occasional TRIs within glomerular endothelial cytoplasm | Positive |
Peleg et al. [6] (1 case) | 46/M/AA | AKI with S. Cr of 12.5 mg/dl, nephrotic-range proteinuria, hypoalbuminemia | Obesity, OSA | Yes (ibuprofen) | LM: CG, ATI/ATN, IF: Neg EM: Sample contained no glomeruli; tubules showed epithelial injury and protein reabsorption droplets but no virions | Positive |
Kissling et al. [7] (1 case) | 63/M/AA | AKI with S. Cr of 4.4 mg/dl, massive proteinuria (5 g/l) and hypoalbuminemia | HTN | Not known | LM: CG, ATI/ATN, IF: Neg EM: no ITEDD present, numerous spherical particlesa within podocyte cytoplasm and within intracytoplasmic vacuoles seen | Not done |
Couturier et al. [8] (2 cases) | a. 53/M/AA b. 53/M/AA | a. AKI with S. Cr of 166 μmol/L (1.8 mg/dl), proteinuria and UPCr 564 mg/mmol (4.9 g/g) b. AKI with S. Cr of 470 μmol/L (5.3 mg/dl), proteinuria and 154.7 mg/mmol (1.3 g/g) | a. HTN b. HTN, untreated chronic hepatitis B | a. Not known b. Not known | a. LM: CG IF: Segmental glomerular deposits of IgM and C3 only EM: Not described b. LM: CG, ATI/ATN, IF: Segmental glomerular staining for C3 only EM: Not described | a. Positive b. Positive |