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Table 1 Study Demographics

From: Nicotinamide riboside with pterostilbene (NRPT) increases NAD+ in patients with acute kidney injury (AKI): a randomized, double-blind, placebo-controlled, stepwise safety study of escalating doses of NRPT in patients with AKI

  Placebo n = 4 Total NRPT n = 20 NRPT Dose
250/50 mg n = 5 500/100 mg n = 5 750/150 mg n = 5 1000/200 mg n = 5
Age (years)
 Mean ± SD 74.0 ± 4.3 68.3 ± 12.8 67.9 ± 7.2 70.4 ± 8.2 62.2 ± 17.3 73.9 ± 6.7
Sex, n (%)
 Male 1 (25) 16 (80) 5 (100) 3 (60) 4 (80) 4 (80)
Race, n (%)
 White 4 (100) 17 (85) 4 (80) 4 (80) 4 (80) 5 (100)
 African American 0 1 (5) 0 1 (20) 0 0
 Asian 0 2 (10) 1 (20) 0 1 (20) 0
 Other 0 0 0 0 0 0
Baseline kidney function, Mean ± SD
 Cr (mg/dl) 1.29 ± 0.25 1.30 ± 0.29 1.37 ± 0.28 1.27 ± 0.16 1.29 ± 0.47 1.26 ± 0.26
 eGFR (ml/min/1.73m2) 47.0 ± 15.4 56.7 ± 14.6 52.4 ± 10.5 54.0 ± 12.9 60.0 ± 19.3 58.6 ± 15.9
 BUN (mg/dl) 49.5 ± 23.0 26.45 ± 11.25 31.2 ± 16.5 23.6 ± 5.9 20.8 ± 9.3 30.2 ± 13.3
Cause of AKI, n (%)
 Drug induced 2 (50) 8 (40) 2 (40) 1 (20) 2 (40) 3 (60)
 Cardiorenal 2 (50) 7 (35) 2 (40) 2 (40) 2 (40) 1 (20)
 Contrast   3 (15) 1 (20) 2 (40)   
 Hypotension   2 (10)    1 (20) 1 (20)
Characteristics of AKI prior to intervention, Mean ± SD
 Days of AKI 2.0 ± 0.8 1.8 ± 0.7 1.6 ± 0.5 2.0 ± 0.7 1.6 ± 0.5 2.0 ± 1.0
 AKIN stage (n) 1 (4) 1 (19), 2 (1) 1 (5) 1 (4), 2 (1) 1 (5) 1 (5)
 UOP (L/day) 1.66 ± 0.91 1.74 ± 0.90 2.00 ± 1.39 1.35 ± 0.80 1.67 ± 0.42 1.94 ± 0.90
  1. Cr creatinine, eGFR estimated glomerular filtration rate, BUN blood urea nitrogen, AKIN acute kidney injury network, UOP urine output