Skip to main content

Table 2 Safety Laboratory Tests

From: Nicotinamide riboside with pterostilbene (NRPT) increases NAD+ in patients with acute kidney injury (AKI): a randomized, double-blind, placebo-controlled, stepwise safety study of escalating doses of NRPT in patients with AKI

  Placebo Step1 Step2 Step3 Step 4
0 h 48 h 0 h 48 h 0 h 48 h 0 h 48 h 0 h 48 h
Cr (mg/dl) 1.52 ± 0.45 1.95 ± 0.40 1.66 ± 0.27 1.62 ± 0.33 1.62 ± 0.48 1.56 ± 0.64 1.9 ± 0.69 1.79 ± 0.84 1.54 ± 0.41 1.62 ± 0.51
eGFR (ml/min/1.73m2) 41.3 ± 21.1 25.0 ± 7.1 43.2 ± 9.9 47.8 ± 11.5 42.0 ± 20.4 50.0 ± 28.1 39.2 ± 13.3 41.3 ± 15.7 46.4 ± 21.8 43.6 ± 17.5
BUN (mg/dl) 45.0 ± 28.1 63.5 ± 29.0 36.8 ± 15.6 34.6 ± 12.1 33.5 ± 9.3 28.0 ± 13.1 35.6 ± 12.6 37.3 ± 9.3 28.4 ± 12.0 28.6 ± 16.2
Na (mEq/l) 140.0 ± 2.2 138.5 ± 0.7 140.6 ± 3.5 138.8 ± 5.1 140.0 ± 2.9 138.3 ± 2.5 140.6 ± 3.6 140.0 ± 2.9 137.2 ± 3.3 136.2 ± 2.6
K (mEq/l) 4.1 ± 0.4 4.0 ± 0.1 4.2 ± 0.5 4.6 ± 0.9 4.3 ± 0.4 4.1 ± 0.2 4.2 ± 0.5 4.5 ± 0.5 4.3 ± 0.5 4.3 ± 0.5
AST (U/l) 20.0 ± 6.6 19.5 ± 2.1 25.0 ± 9.8 60.5 ± 55.9 33.8 ± 12.7 33.0 ± 2.8 27.2 ± 8.6 27.7 ± 17.8 25.6 ± 13.3 24.0 ± 1.9
ALT (U/l) 14.5 ± 3.9 13.0 ± 1.4 24.5 ± 7.1 103.0 ± 117.4 15.8 ± 3.1 18.8 ± 5.7 20.2 ± 12.1 23.0 ± 15.7 15.6 ± 7.5 18.0 ± 6.7
ALP (U/l) 109.8 ± 47.2 105.0 ± 33.9 116.3 ± 64.4 143.5 ± 62.9 148.0 ± 120.2 117.3 ± 65.1 86.3 ± 39.7 91.3 ± 38.5 79.8 ± 29.3 111.6 ± 37.3
WBC (K/μl) 6.9 ± 3.4 8.5 ± 1.4 8.9 ± 2.1 9.0 ± 1.8 10.1 ± 2.9 9.2 ± 2.0 9.3 ± 2.8 8.2 ± 2.3 10.2 ± 5.7 8.8 ± 2.5
Hgb (g/dl) 11.0 ± 2.0 9.9 ± 3.1 10.9 ± 2.9 11.4 ± 3.0 11.1 ± 3.3 10.8 ± 3.3 10.3 ± 1.7 10.7 ± 1.5 11.3 ± 2.0 11.1 ± 2.4
PLT (K/μl) 207.3 ± 37.3 225.5 ± 17.7 202.8 ± 68.7 240.0 ± 28.1 260.5 ± 74.5 234.3 ± 59.4 286.0 ± 136.7 238.0 ± 74.7 268.3 ± 75.6 269.0 ± 108.4
  1. Cr creatinine, eGFR estimated glomerular filtration rate, BUN blood urea nitrogen, Na sodium, K potassium, AST aspartate aminotransferase, ALT alanine aminotransferase, ALP alkaline phosphatase, WBC white blood cells, Hgb hemoglobin, PLT platelets; Data are expressed as laboratory value mean ± standard deviation