Placebo | Step1 | Step2 | Step3 | Step 4 | ||||||
---|---|---|---|---|---|---|---|---|---|---|
0 h | 48 h | 0 h | 48 h | 0 h | 48 h | 0 h | 48 h | 0 h | 48 h | |
Cr (mg/dl) | 1.52 ± 0.45 | 1.95 ± 0.40 | 1.66 ± 0.27 | 1.62 ± 0.33 | 1.62 ± 0.48 | 1.56 ± 0.64 | 1.9 ± 0.69 | 1.79 ± 0.84 | 1.54 ± 0.41 | 1.62 ± 0.51 |
eGFR (ml/min/1.73m2) | 41.3 ± 21.1 | 25.0 ± 7.1 | 43.2 ± 9.9 | 47.8 ± 11.5 | 42.0 ± 20.4 | 50.0 ± 28.1 | 39.2 ± 13.3 | 41.3 ± 15.7 | 46.4 ± 21.8 | 43.6 ± 17.5 |
BUN (mg/dl) | 45.0 ± 28.1 | 63.5 ± 29.0 | 36.8 ± 15.6 | 34.6 ± 12.1 | 33.5 ± 9.3 | 28.0 ± 13.1 | 35.6 ± 12.6 | 37.3 ± 9.3 | 28.4 ± 12.0 | 28.6 ± 16.2 |
Na (mEq/l) | 140.0 ± 2.2 | 138.5 ± 0.7 | 140.6 ± 3.5 | 138.8 ± 5.1 | 140.0 ± 2.9 | 138.3 ± 2.5 | 140.6 ± 3.6 | 140.0 ± 2.9 | 137.2 ± 3.3 | 136.2 ± 2.6 |
K (mEq/l) | 4.1 ± 0.4 | 4.0 ± 0.1 | 4.2 ± 0.5 | 4.6 ± 0.9 | 4.3 ± 0.4 | 4.1 ± 0.2 | 4.2 ± 0.5 | 4.5 ± 0.5 | 4.3 ± 0.5 | 4.3 ± 0.5 |
AST (U/l) | 20.0 ± 6.6 | 19.5 ± 2.1 | 25.0 ± 9.8 | 60.5 ± 55.9 | 33.8 ± 12.7 | 33.0 ± 2.8 | 27.2 ± 8.6 | 27.7 ± 17.8 | 25.6 ± 13.3 | 24.0 ± 1.9 |
ALT (U/l) | 14.5 ± 3.9 | 13.0 ± 1.4 | 24.5 ± 7.1 | 103.0 ± 117.4 | 15.8 ± 3.1 | 18.8 ± 5.7 | 20.2 ± 12.1 | 23.0 ± 15.7 | 15.6 ± 7.5 | 18.0 ± 6.7 |
ALP (U/l) | 109.8 ± 47.2 | 105.0 ± 33.9 | 116.3 ± 64.4 | 143.5 ± 62.9 | 148.0 ± 120.2 | 117.3 ± 65.1 | 86.3 ± 39.7 | 91.3 ± 38.5 | 79.8 ± 29.3 | 111.6 ± 37.3 |
WBC (K/μl) | 6.9 ± 3.4 | 8.5 ± 1.4 | 8.9 ± 2.1 | 9.0 ± 1.8 | 10.1 ± 2.9 | 9.2 ± 2.0 | 9.3 ± 2.8 | 8.2 ± 2.3 | 10.2 ± 5.7 | 8.8 ± 2.5 |
Hgb (g/dl) | 11.0 ± 2.0 | 9.9 ± 3.1 | 10.9 ± 2.9 | 11.4 ± 3.0 | 11.1 ± 3.3 | 10.8 ± 3.3 | 10.3 ± 1.7 | 10.7 ± 1.5 | 11.3 ± 2.0 | 11.1 ± 2.4 |
PLT (K/μl) | 207.3 ± 37.3 | 225.5 ± 17.7 | 202.8 ± 68.7 | 240.0 ± 28.1 | 260.5 ± 74.5 | 234.3 ± 59.4 | 286.0 ± 136.7 | 238.0 ± 74.7 | 268.3 ± 75.6 | 269.0 ± 108.4 |