Table 1 Overview of objectives and measures at different time-points

 To test the effectiveness of the MARS- intervention (experimental group) in promoting medication adherence as measured by Electronic Monitoring in comparison to CAU (control group).

Data from Electronic Monitoring

X

X

X

 To test the effectiveness of the MARS-intervention in promoting the medication adherence as measured by secondary outcome measures in comparison to CAU (control group).

 To test whether the effectiveness of the MARS-intervention on medication adherence sustains after six months (T2-T3).

 To asses when the MARS-intervention influences medication adherence the most.

Questionnaires patient

Medication adherence (BAASIS)

X

X

X

X

Medical data patient file

Intra patient variability (IPV)

X

X

X

X

Rejection of the graft (treatment for rejection)

X

X

Graft loss

X

X

Kidney functioning (eGFR)

X

X

X

X

Collateral report social network

Medication adherence (BAASIS)

X

X

X

X

Collateral report Health Care Professional

Adherent to medication (Y/N)

X

X

X

X

 To test the effectiveness of the MARS-intervention (experimental group) in promoting self-management in comparison to CAU (control group).

Questionnaires patient

Self-management skills (PiH-NL)

X

X

X

X

Medical data patient file

Blood pressure

X

X

X

X

Weight

X

X

X

X

 To test the effectiveness of the MARS-intervention (experimental group) in promoting self-efficacy in comparison to CAU (control group).

Questionnaires patient

Self-efficacy (GSE)

X

X

X

X

 To test the effectiveness of the MARS-intervention (experimental group) in promoting mental health in comparison to CAU (control group).

Questionnaires patient

Quality of life (WHOQoL-Bref)

X

X

X

X

Depression & Anxiety (HADS)

X

X

X

X

Positive & Negative affect (PANAS)

X

X

X

X

 To test the effectiveness of the MARS-intervention (experimental group) in promoting social support in comparison to CAU (control group).

Questionnaires patient

Social support (MOS-SSS)

X

X

X

X

(heiQ- subscale Social Integration and Support)

X

X

X

X

(Self-developed item on who provides support in general and in relation to medication)

X

X

X

X

 To test the effectiveness of the MARS-intervention (experimental group) in promoting mental health among an important other in the social network of the patient in comparison to CAU (control group).

Questionnaires important other

Quality of life (CarerQol-7D)

X

X

X

Depression (PHQ-9)

X

X

X

Anxiety (GAD-7)

X

X

X

Positive & Negative affect (PANAS)

X

X

X

 To test the effectiveness of the MARS-intervention (experimental group) in promoting social support among an important other in the social network of the patient in comparison to CAU (control group).

Questionnaires important other

Social support (MOS-SSS)

X

X

X

(heiQ- subscale Social Integration and Support)

X

X

X

(self-developed item on who provides support)

X

X

X