Table 3 Top 10 most significantly enriched pathways in Cluster 1 and 2 using IPAa
Ingenuity canonical pathway | BHb p-value | Genes |
|---|---|---|
Adipogenesis pathway | 0.0022 | BMP4, BMPR1A, CLOCK, CTBP2, CTNNB1, EGR2, ERCC3,FGF1,FGFR2,FOXC2,FZD2,GTF2H1,GTF2H2,HAT1,HDAC1,HDAC4,HDAC6,HDAC7,HIF1A,KLF5,NFATC4,NR1D2,NR2F2,PPIP5K1,SAP30,SETDB1,SIRT1,SREBF1,TBL1XR1,TGFB1,TNF,TNFRSF1A,TP53,TXNIP,XBP1 |
Aryl hydrocarbon receptor signaling | 0.0044 | ALDH1A3,ALDH1L1,ALDH3A2,ALDH4A1,ALDH6A1,ALDH7A1,CDKN1A,FAS,GSTA1,GSTA2,GSTK1,GSTP1,HSPB2,HSPB7,IL6,MAPK3,MAPK8,MCM7,MDM2,MGST1,MGST3,NCOA7,NCOR2,NFIX,NQO2,NR2F1,RARB,RBL2,SMARCA4,TFF1,TGFB1,TGFB2,TNF,TP53 |
PXR/RXR activation | 0.0044 | ABCC2,ABCC3,AKT2,ALDH3A2,CES2,CES3,CYP3A5,CYP3A7,G6PC,GSTA1,GSTA2,HNF4A,IL6,NCOA1,NR1I3,PCK2,PRKACB,TNF,UGT1A1,UGT1A7 |
Protein ubiquitination pathway | 0.0044 | ANAPC2,ANAPC4,ANAPC5,BIRC2,BIRC6,CRYAA/CRYAA2,CRYAB,DNAJC10,DNAJC12,DNAJC22,DNAJC30,DNAJC7,HLA-A,HLA-B,HLA-C,HLA-E,HSPA2,HSPA4,HSPB2,HSPB7,HSPD1,MDM2,PSMA1,PSMA3,PSMB3,PSMB8,PSMC3,PSMD2,PSME2,SKP1,SKP2,SMURF2,TAP1,UBB,UBE2A,UBE2E1,UBE2E3,UBE2F,UBE2J2,UBE2Q2,UBR2,UCHL1,USP15,USP19,USP2,USP21,USP24,USP28,USP33,USP36,USP4,USP48,USP53,USP54,USP8 |
Xenobiotic metabolism signaling | 0.0044 | ABCC2,ABCC3,ALDH1A3,ALDH1L1,ALDH3A2,ALDH4A1,ALDH6A1,ALDH7A1,ANKRA2,CAMK1G,CAT,CES1,CES2,CES3,CHST1,CHST15,CITED2,CYP3A5,CYP3A7,DNAJC7,EIF2AK3,FMO1,FMO5,GSTA1,GSTA2,GSTK1,GSTP1,HDAC4,HS3ST6,IL6,MAF,MAOA,MAPK14,MAPK3,MAPK8,MAPK9,MGST1,MGST3,NCOA1,NCOR2,NDST2,NQO2,NR1I3,PIK3R4,PPP2R2B,PRKCB,PRKD3,PTPA,RAF1,SULT1C2,SULT2B1,TNF,UGT1A1,UGT1A6,UGT1A7,UGT2B7,UGT8,UST |
Apelin adipocyte signaling pathway | 0.0044 | ADCY3,ADCY5,ADCY6,ADCY7,CAT,CYBB,GNAI2,GPX3,GPX8,GSTA1,GSTK1,GSTP1,HIF1A,MAPK14,MAPK15,MAPK3,MAPK8,MAPK9,MGST1,MGST3,NOX4,PRKAB1,PRKACB |
Death receptor signaling | 0.0085 | ACTB,BIRC2,CASP2,CASP6,CASP7,FAS,HSPB2,HSPB7,IKBKG,LIMK1,MAPK8,PARP11,PARP12,PARP14,PARP6,PARP8,RIPK1,SPTAN1,TANK,TNF,TNFRSF10B,TNFRSF1A,TNFRSF25,TNFSF10 |
LPS/IL-1-mediated inhibition of RXR function | 0.0135 | ABCC2,ABCC3,ABCG1,ACOX2,ACSL4,ALDH1A3,ALDH1L1,ALDH3A2,ALDH4A1,ALDH6A1,ALDH7A1,APOE,CAT,CES2,CHST1,CHST15,CPT1B,CYP3A5,CYP3A7,CYP4A11,FABP1,FMO1,FMO5,GSTA1,GSTA2,GSTK1,GSTP1,HMGCS1,HS3ST6,IL1RL1,MAOA,MAPK8,MAPK9,MGST1,MGST3,NCOA1,NDST2,NR1I3,SLC27A2,SREBF1,SULT1C2,SULT2B1,TNF,TNFRSF1A,UST |
Hepatic fibrosis/hepatic stellate cell activation | 0.0135 | AGTR1,CCL5,COL12A1,COL15A1,COL16A1,COL18A1,COL1A2,COL3A1,COL4A3,COL4A5,COL5A2,COL5A3,COL6A1,COL6A2,COL6A3,COL7A1,CSF1,ECE1,EDNRB,FAS,FGF1,FGFR2,FN1,IGF2,IL1RL1,IL6,IL6R,KLF6,LEPR,MYL6B,PDGFA,PDGFRB,SMAD4,TGFA,TGFB1,TGFB2,TIMP1,TNF,TNFRSF1A |
TR/RXR activation | 0.0135 | ACACA,AKR1C1/AKR1C2,AKT2,BCL3,COL6A3,DIO1,G6PC,GPS2,HIF1A,LDLR,MDM2,NCOA1,NCOR2,PCK1,PIK3R4,SLC16A2,SLC16A3,SREBF1,SREBF2,TBL1XR1,THRA,UCP2 |